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Primary progressive multiple sclerosis (PPMS) – cerebrospinal fluid (CSF) profile

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Thesis_Abdelhak.pdf (1.380Mb)
Erstveröffentlichung
2018-01-10
Authors
Abdelhak, Ahmed
Referee
Tumani, Hayrettin
Vasic, Nenad
Dissertation


Faculties
Medizinische Fakultät
Institutions
UKU. Klinik für Neurologie
Abstract
Objective The aim of this study was to report the basic cerebrospinal fluid (CSF) profile in patients with primary progressive multiple sclerosis (PPMS). Methods The results of CSF analysis from 254 patients with PPMS were collected at four university hospitals in Germany. Routine CSF parameters and different indices of intrathecal immunoglobulin synthesis were evaluated. We assessed possible correlations between the various CSF parameters and the expanded disability status scale (EDSS) both at the time of lumbar puncture and during the course of the disease. Results The median cell count and albumin concentration in the CSF did not deviate from normal values. The CSF-serum albumin-quotient (QALB) was elevated in 29.6% of the patients, while intrathecal immunoglobulin G (IgG) oligoclonal bands (OCBs) were detected in 91.1% of the patients. CSF-lactate levels as well as local IgM- and IgA-synthesis were correlated with the yearly disease progression rate, as assessed by EDSS. Conclusion We present the results of the hitherto largest and most detailed CSF biomarker profile in a cohort of 254 patients with PPMS. As reported previously, OCBs are the most sensitive marker for intrathecal IgG synthesis. CSF-lactate concentrations are positively correlated with the progression rate, which might suggest that mitochondrial dysfunction plays a relevant role in PPMS. The negative correlation between intrathecally produced IgM and IgA and disease progression may indicate their hitherto unexplored protective role.
Date created
2016
Subject headings
[GND]: Multiple Sklerose | Liquor cerebrospinalis | Lactate
[MeSH]: Multiple sclerosis | Chromosome banding | Lactates | Cerebrospinal fluid | Multiple sclerosis, chronic progressive
[Free subject headings]: PPMS | MS | CSF | Oligoclonal bands
[DDC subject group]: DDC 610 / Medicine & health
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-5285

Abdelhak, Ahmed (2018): Primary progressive multiple sclerosis (PPMS) – cerebrospinal fluid (CSF) profile. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-5285
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