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Progress in evidence-based medicine by critical appraisal of evidence-based medicine: the HOST catalogue : concordance of study hypothesis, objective, statistics and translation

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ConcordanceDiss.pdf (618.9Kb)
Erstveröffentlichung
2021-11-29
Authors
Phlippen, Meret Sophie
Referee
Porzsolt, Franz
Weiß, Manfred
Dissertation


Faculties
Medizinische Fakultät
Institutions
UKU. Klinik für Allgemein- und Viszeralchirurgie
UKU. Klinik für Anästhesiologie und Intensivmedizin
Abstract
As an incidental finding of earlier scientific work, the impression was created that the described hypothesis in a clinical study was not always in concordance with the declared study objective and the statistical test applied. Therefore, we set ourselves the task to describe the concordance of the study hypothesis with the study objective and with the application of the statistical tests in 120 studies from six different disciplines. The most significant effect was seen in the considerable deviation in studies using a two-sided test and simultaneously formulating a one-sided hypothesis. This means that more patients are included in an experimental study and more patients are exposed to a human experiment. We have recorded the results of our project under the so-called HOST catalogue: we plead for the clear statement of the study Hypothesis and the study Objective, the matching application of the Statistical testing and the correct Translation of the study results. In order to make studies more ethical, we propose to ensure that the clearly stated study hypothesis is in concordance with the clearly stated study objective and in concordance with the statistical test when conducting a study.
Date created
2020
Subject headings
[GND]: Randomisierter Test | Medizinische Ethik
[MeSH]: Randomized controlled trials as topic | Statistics as topic; Standards | Ethics, Clinical
[Free subject headings]: Concordance | Hypothesis objective | One-sided testing | Two-sided testing
[DDC subject group]: DDC 610 / Medicine & health
License
CC BY-NC 4.0 International
https://creativecommons.org/licenses/by-nc/4.0/

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-40045

Phlippen, Meret Sophie (2021): Progress in evidence-based medicine by critical appraisal of evidence-based medicine: the HOST catalogue : concordance of study hypothesis, objective, statistics and translation. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-40045
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