Characterization of the effects of Endophilin A3 on the physiological properties of SK3 channels
InstitutionsInstitut für Angewandte Physiologie
Small conductance calcium-activated (SK) channels play an important role by controlling the after-hyperpolarization of excitable cells. The level of expression and density of these channels is an essential factor for controlling different cellular functions. Several studies showed a co localization of KCa2.3 channels and Endophilin A3 in different tissues. Endophilin A3 belongs to a family of BAR- and SH3 domain containing proteins that bind to dynamin and are involved in the process of vesicle scission in clathrin-mediated endocytosis. In addition it has been found that Endophilin A3 interacts with SK3 channels reducing thereby the channel activity. The purpose of the current work is to further investigate the effects of the interaction of Endophilin A3 on the physiological properties of SK3 channels.
Subject HeadingsCalciumkanal [GND]
Calcium channels [MeSH]