Klinikopathologische Merkmale und Outcome bei 133 extragastrointestinalen Stromatumoren unter Berücksichtigung der Lokalisation im Vergleich mit 976 gastrointestinalen Stromatumoren des Magens und des Dünndarms
Extra gastrointestinal stromal tumors (EGIST) are a rare subgroup of gastrointestinal stromal tumors (GIST). In this dissertation, 133 EGIST were evaluated in comparison to 976 gastral and intestinal GIST. Age, tumor size, rate of mitosis, histomorpholgy, immunhistochemistry, genetic profile, therapy and outcome were compared. To further differentiate, the EGIST group was split into subgroups according to tumor localization. Because of obvious differences, statistical analysis of omental and mesenterial EGIST in comparison with all other EGIST was performed. In addition, omental EGIST were compared to gastral GIST and mesenterial EGIST to intestinal GIST, as well as with each other to evaluate a hypothesis according to which omental EGIST and gastral GIST and mesenterial EGIST and intestinal GIST are similar. As far as we know, this dissertation is the first study to involve more than a hundred EGIST. The most common location for EGIST are the omentum, the mesentery and the retroperitoneum. Results showed significant differences between EGIST and GIST: Younger patients, larger tumors and a less favourable outcome. Tumor size, rather than rate of mitosis, seems to be responsible for the less advantageous outcome. Significant differences in histomorphology (more epitheloid/mixed cell type), immunhistochemistry (c-Kit-negativity) and genetic profile (more wild type EGIST) also occurred. EGIST of the omentum and mesenterium showed less recurrence/metastases than all other EGIST which might be influenced by certain histological, immunhistochemical and genetic characteristics. The hypothesis concerning the similarity between omental/mesenterial EGIST and gastral/intestinal GIST could not be confirmed by the results, as several significant differences were shown. In conclusion, EGIST and GIST appear to have different characteristics. EGIST appear to be more aggressive with less favourable outcome. This needs to be considered from a clinico-therapeutic point of view.
Subject HeadingsGastrointestinale Krankheit [GND]
Gastrointestinaler Tumor [GND]
Gastrointestinal stromal tumors [MeSH]