Pulmonale Morbidität bei sehr unreifen Frühgeborenen unter Verwendung einer noninvasiven Erstversorgungs- und Beatmungsstrategie
Parys, Elisa Marja
LicenseCC BY-NC-ND 3.0 Deutschland
This manuscript describes strategies for initial assistance and ventilation strategies of very preterm infants (< 29 GW), including sustained inflations and associated complications, especially air-leaks. 297 very preterm infants, born between 10th November 2004 and 17th of August 2009 at the University Hospital of Ulm (Germany) were included. Two groups were compared with an univariate analysis: with and without air-leaks. Several parameters showed a significant association with air-leaks. To identify possible risk factors for air-leaks a multivariate logistic regression analysis was performed. Application of prenatal steroids (OR 0.41), epinephrin (OR 1.55) and surfactant (OR 12.03) remained significant, while use of sustained inflations with a pressure of 30cmH20 showed no significant effect on air-leaks. Furthermore the Ulm cohort is compared with the two groups of the international and multicenter COIN study (CPAP and intubation group). A lower mortality and lower rate of BPD was found in Ulm. Noninvasive ventilation strategies showed high rates of Pneumothorax in both studies, but PIE were found more frequently in Ulm.
Subject HeadingsFrühgeborenes [GND]
Künstliche Beatmung [GND]
Infant, extremely premature [MeSH]
Respiration, artificial [MeSH]