Inzidenz und prognostische Bedeutung von NPM1-Mutationen bei der akuten myeloischen Leukämie des Erwachsenen: Analysen im Rahmen der AML HD98-A Studie

Abstract

NPM1 is an ubiquitary phosphoprotein, it has different effects to the signal path way of for example tumor suppressor gene TP53. The incidence and prognostic meaning of NPM1 mutations in the AML with aberrant karyotype is discussed within this dissertation. In the context of this dissertation data from 790 patients were analysed.