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Glioblastoma : the effects of the dual kinase inhibitor PI-103 on glioblastoma cells

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Erstveröffentlichung
2020-08-04
Authors
Ströbele, Stephanie
Referee
Halatsch, Marc-Eric
Knippschild, Uwe
Dissertation


Faculties
Medizinische Fakultät
Institutions
UKU. Klinik für Neurochirurgie
UKU. Klinik für Allgemein- und Viszeralchirurgie
Abstract
Glioblastoma is the most common primary brain tumour in adults. Under the current first-line therapy with surgical resection as well as radiotherapy and concomitant or adjuvant chemotherapy, the median survival rate is only about 16 months, so that new therapies are urgently needed. In 88% of all glioblastoma patients, changes in the PI3K signalling pathway are found. Therefore in this study the influence of the inhibition of the PI3K signalling pathway on glioblastoma cells was investigated using the dual kinase inhibitor PI-103. It was shown that inhibition of the PI3K pathway can successfully inhibit the proliferation of both differentiated cells and stem cells. Furthermore, the migration of differentiated cells can be significantly reduced. Unfortunately, however, no effect on the apoptosis of the cells could be achieved and a sensitization to apoptosis triggered by chemotherapy was not possible.
Date created
2019
Subject headings
[GND]: Glioblastom | Stammzelle | Zelldifferenzierung
[MeSH]: Glioblastoma | Stem cells | Cell differentiation
[Free subject headings]: PI-103 | Differentiated cells
[DDC subject group]: DDC 570 / Life sciences | DDC 610 / Medicine & health
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https://oparu.uni-ulm.de/xmlui/license_v3

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-32452

Ströbele, Stephanie (2020): Glioblastoma : the effects of the dual kinase inhibitor PI-103 on glioblastoma cells. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-32452
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