Sonographische und anthropometrische Fettparameter als Prädiktoren eines Metabolischen Syndroms und einer Steatosis hepatis bei übergewichtigen Kindern und Jugendlichen
Sonographische und anthropometrische Fettparameter als Prädiktoren eines Metabolischen Syndroms und einer Steatosis hepatis bei übergewichtigen Kindern und Jugendlichen. Purpose: Our study aimed to identify and compare sonographic and anthropometric parameters, highly associated with the presence of nonalcoholic fatty liver disease (NAFLD) and the Metabolic Syndrome (MetS) in overweight children and adolescents. Material and methods: 447 overweight children and adolescents (Body Mass Index (BMI) 32.4 ± 5.2 kg/m2; mean age 14.2 ± 1.9y) were analyzed. Using ultrasound we detected the presence of fatty liver disease, the amount of adipose tissue above the biceps and triceps, subscapular, suprailiac and abdominal subcutaneous adipose tissue and the intraabdominal depth (IAD). In addition we reported the anthropometric parameters BMI, BMI-Standard-Deviation Score, waist circumference (WC) and waist-to-hip ratio (WHR). MetS was identified using the criteria of the International Diabetes Federation. Results: The prevalence of NAFLD in the studied population was 27.1 %. MetS was diagnosed in 26.6 %. NAFLD and MetS were significantly associated with all anthropometric parameter evaluated (p < .001), except for MetS with WHR. Using ultrasound, significant associations were found between the amount of subscapular, suprailiac and abdominal subcutaneous adipose tissue and IAD and NAFLD (p < .001) as well as between the MetS and these parameters of central fat distribution. The stepwise logistic regression analysis in females and males showed only the IAD (female p = 0.0019; male p < .0001) and the deposit of subcutaneous suprailiac adipose tissue (female p=0,0051; male p = 0.0047) to be independent predictors of NAFLD. BMI was identified as an independent predictor of MetS as well in the female (p = 0.033) as in the male cohort (p < .0001).
Subject HeadingsAnthropometrie [GND]
Metabolisches Syndrom [GND]
Body mass index [MeSH]
Fatty liver [MeSH]
Overweight; In adulthood [MeSH]
Overweight; In infancy and childhood [MeSH]