Der Einfluss von HLA-E Polymorphismen auf den Erfolg der nichtverwandten Stammzelltransplantation - eine retrospektive Analyse -
Although HLA-E is not a classical MHC-Ia mulecule, differential expression of HLA-E alleles on the cell surface has been reported to influence outcome of hematopoietic stem cell transplantation. HLA-E is interacting with natural killer cells and T-cells via the CD94/NKG2x Receptor. Especially the six fold higher affinity to the inhibitory receptor seems to play an important role. Previously published data on HLA-E polymorphism and hematopoietic stem cell transplantation has shown conflicting results. We genotyped 116 patients and their HLA matched unrelated donors for HLA-E and analysed the impact of HLA-E genotypes on patient overall-survival (OS), disease-free-survival (DFS) as well as cumulative incidences for relapse, transplant-related-mortality (TRM) and acute Graft versus Host Disease (aGvHD). We could not detect any influence of HLA-E polymorphisms on the investigated endpoints in our statistical univariaten and multivariate analyse.
Subject HeadingsHeptakis(2,3,6-tri-O-(sodium 5-carboxyl-3-thiapentyl))-cyclodextrin [MeSH]
Stem cells [MeSH]