Adipokine-Bindeglieder zwischen Adipositas und Brustkrebs
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In this study we investigated the association between obesity, adipokines and breast cancer. We specifically analysed differences in the serum levels of A-FABP (adipocyte fatty acid binding protein), leptin and adiponectin in women with breast cancer in comparison to women with benign lesions. In addition we investigated the influences of menopausal status and obesity on the serum levels of the adipokines as well as the association between adipokine serum levels and tumor characteristics. We included 159 patients with histologically confirmed breast cancer and 41 women with benign lesions, who formed our control group. The serum levels of the adipokines were measured by ELISA (=enzyme linked immunosorbent assay). The logistic regression model was adjusted for age, BMI (=body mass index), menopausal status, hormone replacement therapy and family history of breast cancer. Independent of these variables, an association between serum level of A-FABP and breast cancer risk was evident. Despite this, an association between serum level of A-FABP and obesity, tumor size and positive lymph nodal status was found. The serum levels of leptin showed a significant correlation with BMI and appeared to be elevated in patients compared to controls. There was no association between adiponectin and breast cancer.
Erstellung / Fertigstellung
Normierte SchlagwörterAdipokine [GND]
Breast neoplasms [MeSH]