Praxis der medikamentösen Behandlung fokaler Epilepsien am Beispiel des Zentrums für Psychiatrie Südwürttemberg in Weissenau
Background: Despite the introduction of several new antiepileptic drugs in the last 20 years and general treatment guidelines concerning epilepsy one-third of epilepsy patients still suffer from persistent seizures and side-effects of the anticonvulsive therapy. This often leads to a severe impact on social life and quality of life. The question is whether and to which extent the existing treatment guidelines are adhered in everyday clinical practice and what are the chances of success of a guideline-based therapy in a specialised epilepsy centre. Methods: In a retrospective study, 90 Patients with focal epilepsy were recruited from a tertiary epilepsy centre. All data concerning the medical treatment, the effectiveness of the antiepiletic drugs and the side-effects were analyzed. Results: In total 62,2 % (56/90) of the patients were classified as responders to the pharmacological treatment with a decrease in seizure frequency of more than 35 %. In contrast a complete seizure remission could only be achieved by 34,4 % (31/90) of the patients. Side-effects are a very common problem in the long-term treatment of epilepsy and had been observed in 66,7 % (60/90) of the study population. Conclusion: The present study shows that in spite of an appropiate anticonvulsive treatment and adherence to the treatment guidelines, a considerable part of patients with focal epilepsy suffer from persistent seizures and side-effects of therapy. Therefore it is necessary to enhance the pharmacological therapy in epilepsy and to evolve new therapeutic strategies.
Subject HeadingsEpilepsie [GND]