Zusammenhang von Ernährungsfaktoren mit der Dichte des Brustgewebes.
Auch gedruckt in der BibliothekW: W-H 13.129
Ressourcen- / MedientypDissertation, Text
Datum der Freischaltung2012-12-14
Background: Effects of dietary factors, such as adherence to the Mediterranean dietary pattern, multivitamin-multimineral supplements use and alcohol consumption on mammographic breast density, an important biomarker of breast cancer risk, are not sufficiently consistent to elaborate preventive recommendations. This study aims to investigate the association between these factors and mammographic density. Methods: We performed a cross-sectional study in 424 pre- and post-menopausal women. Current Mediterranean type dietary pattern, multivitamin-multimineral supplements use, alcohol consumption and potential confounders were assessed with a self-administered questionnaire in the mammography unit of University Hospital Ulm (2007 - 2008). Radiologists evaluated mammographic density according to an American College of Radiology (ACR) classification, which was summarized in low = ACR1/2 and high = ACR3/4 mammographic density. Logistic regression models were used to assess the association between current dietary intake and mammographic density, adjusted for age, Body-Mass-Index. Results: A Mediterranean type dietary pattern was inversely associated with a mammographic density, adjusted for age and Body-Mass-Index (per 1 unit increase of score OR 0.95; 95 % CI 0.90 - 0.997). Current use of multivitamin-multimineral supplements was also inversely associated with a mammographic density in the adjusted model (OR 0.53; 95 % CI 0.34 - 0.83). Compared to non-drinkers, excessive alcohol consumption (10 - 47 g/d) was positively associated with mammographic density in the adjusted model (OR 1.47; 95 % CI 0.82 - 2.63). Conclusions: Adherence to Mediterranean type diet and current use of multivitamin-multimineral supplements were associated with lower mammographic density and may suggest a protective effect against breast cancer.