Die Bioelektrische Impedanzanalyse bei Patienten mit einer Amyotrophen Lateralsklerose - Eine prospektive Pilotstudie
Auch gedruckt in der BibliothekW: W-H 13.068
Ressourcen- / MedientypDissertation, Text
Datum der Freischaltung2012-10-17
The amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of the first and second motor neurons. It is known that malnutrition is a negative prognostic factor in ALS patients. The bioelectrical impedance analysis is a non-invasive method to investigate nutritional status. The aim of this prospective study with 54 ALS patients was to test the applicability of this method in this patient collective and the prognostic value of the obtained parameters. We found that several parameters are useful to detect malnutrition in ALS patients; especially phase angle and body cell mass (BCM) are relevant prognostic values. Catabolism as shown by the ECM/BCM index (ECM=extra cellular mass) was identified in almost all patients. In contrast to published data we exclusively found an elevated resting energy expenditure in the very late stage of the disease. In conclusion, the bioelectrical impedance analysis is a valid method to describe body composition and can give important additional information concerning nutritional status of ALS patients.