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Pulmonale Inflammationsreaktion bei beatmeten Frühgeborenen unter NO-Inhalation

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vts_8084_11775.pdf (1.241Mb)
77 S.
Veröffentlichung
2012-07-23
Authors
Amann, Elena
Dissertation


Faculties
Medizinische Fakultät
Abstract
Empirical studies have shown a positive effect of inhaled nitric oxide in newborn infants as a method to reduce the incidence of pulmonary hypertension. Drawing on these findings the EUNO-study explores the impact of inhaled nitric oxide in premature infants to reduce the incidence of bronchopulmonary dysplasia. As part of the EUNO-study we tested the hypothesis that the measured values of cytokines (IL-1beta, IL-6, IL-8, LTB4, TGF-beta1, MIP-1alpha, IP-10, NPY), ASM and Albumin will reduce and that the measured values of Nitrit/Nitrat and Nitrotyrosin will increase using inhaled nitric oxide in premature infants in comparison to inhaled placebo gas. We conducted a double-blind study with N = 43 participants who were randomly assigned to an experimental group (inhaled nitric oxide, 5 parts per million) or a control group (inhaled placebo nitrogen gas). Tracheal secretion was collected for a minimum of 7 days and a maximum of 21 days. The tracheal secretion served as material for the immunological analysis. With regard to the parameters, our inconsistent results show further important findings in relation to inhaled nitric oxide. However the effects also demonstrate that the impact of inhaled nitric oxide is not exhaustively clarified.
Date created
2011
Subject headings
[GND]: Bronchopulmonale Dysplasie | Frühgeborenes | Stickstoffmonoxid
[MeSH]: Bronchopulmonary dysplasia | Infant, premature
[Free subject headings]: BPD | NO
[DDC subject group]: DDC 610 / Medicine & health
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-2696

Amann, Elena (2012): Pulmonale Inflammationsreaktion bei beatmeten Frühgeborenen unter NO-Inhalation. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-2696
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