Pulmonale Inflammationsreaktion bei beatmeten Frühgeborenen unter NO-Inhalation

Abstract

Empirical studies have shown a positive effect of inhaled nitric oxide in newborn infants as a method to reduce the incidence of pulmonary hypertension. Drawing on these findings the EUNO-study explores the impact of inhaled nitric oxide in premature infants to reduce the incidence of bronchopulmonary dysplasia. As part of the EUNO-study we tested the hypothesis that the measured values of cytokines (IL-1beta, IL-6, IL-8, LTB4, TGF-beta1, MIP-1alpha, IP-10, NPY), ASM and Albumin will reduce and that the measured values of Nitrit/Nitrat and Nitrotyrosin will increase using inhaled nitric oxide in premature infants in comparison to inhaled placebo gas. We conducted a double-blind study with N = 43 participants who were randomly assigned to an experimental group (inhaled nitric oxide, 5 parts per million) or a control group (inhaled placebo nitrogen gas). Tracheal secretion was collected for a minimum of 7 days and a maximum of 21 days. The tracheal secretion served as material for the immunological analysis. With regard to the parameters, our inconsistent results show further important findings in relation to inhaled nitric oxide. However the effects also demonstrate that the impact of inhaled nitric oxide is not exhaustively clarified.