Biomechanische In-vitro-Untersuchungen zum Extrusionsrisiko von Gelen als Zellträgermaterial für die regenerative Bandscheibentherapie
Biomechanical in-vitro testing of two gel-like implants for the regenerative disc therapy. For this study 18 monosegmental specimens of the a bovine lumbar spine were used. The implants were of a gel-like structure, consisting of two fluid parts, polymerizing after injection. They were implanted in the center of the nucleus pulposus and are supposed to be cultured with nucleus cells or stem cells in the future. Disc height, NZ and ROM were documentes during a cyclic loading test. During the test no extrusion was seen. After implantation a lightly - but significant - stabilisation of the segment was achieved. During the cyclic loading test an increase in ROM an a decrease in disc high was documented, comparable to the behaviour of the control group. Given under the testing conditions - also seen as a "worst-case szenario" - both implants seem to be an option for regenerative disc therapy. Further testing on human degenerated discs is recommended.
Erstellung / Fertigstellung