Einfluss des Körpergewichts auf die linksventrikuläre Muskelmasse unter besonderer Berücksichtigung der Körperfettverteilung - Ergebnisse der URMEL-ICE Studie
In this study the influence of body weight on the left ventricular mass in childhood, with special regard to body fat distribution, has been examined. The data was provided by the URMEL-ICE trial, in which 1120 children aged between 6 and 9 years were examined. The results showed that obese boys have four times and obese girls even have seven times more often left ventricular hypertrophy than children of normal body weight. Abdominal fat distribution and especially the visceral fat in adulthood as a marker for the prevalence of cardiovascular risk factors having become more important over the last years and this circumstance also having been discussed in latest studies for childhood, this feature has been given special attention. The abdominal fat distribution has been represented in this study by waist circumference and the sonographically determined intraabdominal fat. Both the waist circumference and the intraabdominal fat show significantly higher values in children with left ventricular hypertrophy than in children with normal left ventricular mass. So even in prepuberal children there is a disadvantageous effect of abdominal fat distribution on the prevalence of the cardiovascular risk factor being left ventricular hypertrophy, mostly independent of the hormonally induced sexual development. These data underline the necessity of preventive medical programs for weight reduction, with special attention to the kind of fat distribution, from as early as preschool age. Regarding the predictive value for a left ventricular hypertrophy, measuring the waist circumference shows an advantage over the sonographically determined intraabdominal fat. Being device-independent, simple to handle, cheap and mostly independent of inter- and intraobservervariability, this would be a parameter easy to integrate in preventive programs.