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Vergleichende Untersuchung der Telomerverlängerungsmechanismen in Zellen mit normalem und aberrantem Karyotyp

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157 Seiten
Veröffentlichung
2011-08-15
Authors
Hesse, Raffaella
Dissertation


Faculties
Medizinische Fakultät
Abstract
In human tumor cells, two types of telomere maintenance mechanisms are described: one depends on the synthesis of telomeric repeats by the enzyme telomerase, the other on the so-called alternative pathway (ALT), which is based on telomere recombination. In this study different tumor cell lines and lymphoblastoid cell lines were examined for their telomerase activity via immunhistochemistry and TRAP assay and their ALT pathway through the enzymes RPA-2 and RPA-4. All examined cell lines showed positive telomerase activity which was negatively correlated with donor age. A possible relation with immortalisation by Epstein-Barr virus and histological origin is discussed. Although RPA-2 and RPA-4 are parts of the replication protein complex and involved in DNA repair via homologous recombination, both enzymes turn out not to be useful markers for the ALT pathway.
Date created
2010
Subject headings
[GND]: Epstein-Barr-Virus | Telomer <Molekulargenetik> | Telomerase | Verlängerung
[MeSH]: Herpesvirus 4, human | Replication protein A
[Free subject headings]: ALT | LCL | RPA
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 01.10.2008)
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Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-2235

Hesse, Raffaella (2011): Vergleichende Untersuchung der Telomerverlängerungsmechanismen in Zellen mit normalem und aberrantem Karyotyp. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-2235
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