Einfluss des 5-, 10-Methylentetrahydrofolatreduktase (MTHFR)-Polymorphismus C677T auf den Erfolg einer extrakorporalen Befruchtung
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A retrospective surveillance was performed to ascertain the influence of the 5-,10- Methylenetetrahydrofolate Reductase C677T Mutation on the outcome of IVF and ICSI treatment. 531 couples (966 treatments) were monitored from January 1998 to December 2005. The men in the ICSI treatment group had significant more mutations in the MTHFR than the men in the IVF treatment group. In the IVF group the MTHFR mutation had a significant influence on the clinical pregnancy and birth rate. In the ICSI group the influence of the MTHFR mutation on the outcome of ICSI was not significant. Conclusion: The MTHFR mutation c677t seems to influence the outcome of ART (assisted reproductive technology).
Subject HeadingsFolsäure [GND]
Intracytoplasmatische Spermatozoeninjektion [GND]
Fertilization in vitro [MeSH]
Sperm injections, intracytoplasmic [MeSH]