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Levothyroxin bei euthyreoter Autoimmunthyreoiditis und Typ 1 Diabetes mellitus: eine randomisierte, kontrollierte Studie

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49 Seiten
Veröffentlichung
2008-12-19
Authors
Rapp, Andrea
Dissertation


Faculties
Medizinische Fakultät
Abstract
Our objective was to determine wheter levothyroxine (L-T4) treatment prevents the clinical manifestation of AIT in euthyroid subjects with T1D. We conducted a prospective, randomized, open, controlled trial. L-T4 was given for 24 months in the treatment group, followerd by an additional observation period of 6 months in both groups. Mean thyroid volume decreased in the treatment group after 24 months (-0,6 SD score) and increased in the observation group (+1,11 SD score; p = 0,0218). Conclusions: In this study in euthyroid patients with AIT and T1D, L-T4 treatment reduced thyroid volume but had no effect on thyroid function and serum autoantibody levels.
Date created
2008
Subject headings
[GND]: Thyreoiditis | Thyroxin <L->
[MeSH]: Diabetes mellitus | Thyreoiditis, autoimmune
[Free subject headings]: Autoimmune thyreoiditis | Euthyroid
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 01.10.2008)
https://oparu.uni-ulm.de/xmlui/license_v2

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-1529

Rapp, Andrea (2008): Levothyroxin bei euthyreoter Autoimmunthyreoiditis und Typ 1 Diabetes mellitus: eine randomisierte, kontrollierte Studie. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-1529
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