Bedeutung von KH-domain containing protein overexpressed in cancer (KOC) als Marker zur Diagnostik einer Manifestation von malignen Erkrankungen im ZNS
LicenseStandard (Fassung vom 03.05.2003)
Morphological evaluation of cerebrospinal fluid (CSF) samples by microscopy is still the method of choice for the detection of central nervous system involvement in patients especially with haematological malignancies. But, because morphological analysis of CSF in patients suspected of leptomeningeal involvement (LI) is false negative in one-third of patients, a supplementary diagnostic marker would be very valuable. The aim of this study was to examine the expression and value of the novel molecular indicator of malignancy called KOC (KH-domain containing protein overexpressed in cancer), a novel onco-foetal gene, at diagnosis of LI. 62 patients underwent lumbar puncture and CSF were examined by cytology and by a KOC RT-PCR assay. 43 patients (reactive changes in CNS, myeloid and lymphoid leukemias, lymphomas and solid tumours) with a clear cytology and KOC RT-PCR were included in this study. The expression of KOC showed a sensitivity of 60% and a specifity of 94%. The advantage of this method seems to be the good differentiation between malignant and reactive cells. Also the results at the immature leukemias and lymphomas are very interesting and further examinations should be done to prove the exact role of this new diagnostic tool.
Subject HeadingsAkute myeloische Leukämie [GND]