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Histologische und biochemische Charakterisierung der autochthonen Rückenmuskulatur (M. erector spinae) bei neuromuskulär gesunden Patienten

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Erstveröffentlichung
2018-12-11
Authors
Zimmermann, Claudia
Referee
Kassubek, Jan
Bieger, Ralf
Dissertation


Faculties
Medizinische Fakultät
Institutions
Rehabilitationskrankenhaus Ulm
UKU. Klinik für Orthopädie
UKU. Klinik für Neurologie
Abstract
There are no generally accepted histopathological reference values in paraspinal skeletal muscle biopsies. Methods: We examined multifidii muscle biopsies from 20 neuromuscularly healthy subjects using routine histological stains and biochemical analyses of respiratory chain enzymes. Results: Staining showed incomplete myopathic features, such as increased variability in fiber size, type 1 hypertrophy, rounded fiber shape, endomysial fibrosis, and replacement by adipose tissue. Acid phosphatase reaction was positive in up to 35% of the selected muscle fibers. Mitochondrial changes were obvious but revealed no selective age dependence. Reduced complex I, cytochrome c oxidase (COX), and citrate synthase (CS) could be observed.Conclusions: Because the increased variability in morphological details can easily be misinterpreted as myopathic changes, analysis of paraspinal muscles should take into consideration that incomplete myopathic features and reduced oxidative enzyme activities for complex I, COX, and CS are normal variations at this location.
Date created
2018
Subject headings
[GND]: Rückenmuskulatur
[MeSH]: Back muscles; Anatomy & histology
[Free subject headings]: Autochthone Rückenmuskulatur | Dropped Head Syndrom | Bent Spine Syndrom
[DDC subject group]: DDC 610 / Medicine & health
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-10688

Zimmermann, Claudia (2018): Histologische und biochemische Charakterisierung der autochthonen Rückenmuskulatur (M. erector spinae) bei neuromuskulär gesunden Patienten. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-10688
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