FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons

Higelin, Julia; Demestre, Maria; Putz, Stefan; Delling, Jan P.; Jacob, Christian; Lutz, Anne-Kathrin; Bausinger, Julia; Huber, Anne-Kathrin; Klingenstein, Moritz; Barbi, Gotthold; Speit, Guenter; Huebers, Annemarie; Weishaupt, Jochen H.; Hermann, Andreas; Liebau, Stefan; Ludolph, Albert C.; Böckers, Tobias M.

Erstveröffentlichung

2016

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Wissenschaftlicher Artikel

Authors

Higelin, Julia

Demestre, Maria

Putz, Stefan

Delling, Jan P.

Jacob, Christian

et al.

Faculties

Medizinische Fakultät

Institutions

Institut für Anatomie und Zellbiologie
UKU. Klinik für Neurologie
UKU. Institut für Humangenetik

Published in

Frontiers in Cellular Neuroscience ; 10 (2016). - Art.-Nr. 290. - ISSN 1662-5102

Link to publication

https://dx.doi.org/10.3389/fncel.2016.00290

Funding information

Virtual Helmholtz Institute within the Helmholtz Gesellschaft ({''}RNA Dysmetabolism in ALS and FTD{''}) [VH-VI-510]
Bundesministeriums fur Bildung and Forschung (BMBF) ({''}MND-NET{''}) [01GI0704]
EURO-MOTOR / European multidisciplinary ALS network identification to cure motor neuron degeneration / EC / FP7 / 259867

Keywords

hiPSC; FUS; ALS; motoneuron; neurodegeneration; DNA damage; FTLD; amyotrophic-lateral-sclerosis; pluripotent stem-cells; rna-binding protein; frontotemporal lobar degeneration; dendritic spines; motor-neurons; sarcoma fus; stress granules; ipsc models; mutations

Dewey Decimal Group

DDC 610 / Medicine & health

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