Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging

Erstveröffentlichung
2015
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Wissenschaftlicher Artikel

Authors
Japtok, Julia
Lojewski, Xenia
Naumann, Marcel
Klingenstein, Moritz
Reinhardt, Peter
et al.
Faculties
Medizinische Fakultät
Institutions
Institut für Anatomie und Zellbiologie
UKU. Klinik für Neurologie
Published in
Neurobiology of Disease ; 82 (2015). - S. 420-429. - ISSN 0969-9961. - eISSN 1095-953X
Link to publication
https://dx.doi.org/10.1016/j.nbd.2015.07.017
Funding information
Deutsche Gesellschaft fur Muskelerkrankungen [He 2/2]
Roland Ernst Stiftung Saxony [03/14]
MeDDrive program of the Medical Faculty at the Technische Universitat Dresden
BIOCREA GMBH
Helmholtz Virtual Institute [VH-VI-510]
Keywords
Amyotrophic lateral sclerosis; Frontotemporal dementia; Fused in sarcoma; Translated in sarcoma; RNA granules; Stress granules; Aggregate prone disease; Disease spreading; Cortical neurodegeneration; Motor neuron disease; FUS-FTLD; iPSC; Human cell models; amyotrophic-lateral-sclerosis; frontotemporal lobar degeneration; nuclear-localization signal; pluripotent stem-cells; wild-type fus; sarcoma fus; mutant fus; fet proteins; rna
Dewey Decimal Group
DDC 610 / Medicine & health
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