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AuthorKuch, Holgerdc.contributor.author
Date of accession2016-03-14T11:54:13Zdc.date.accessioned
Available in OPARU since2016-03-14T11:54:13Zdc.date.available
Year of creation2001dc.date.created
AbstractA method for the analysis of phenolic estrogenic active compounds in surface and drinking water in the picogram/liter-range is described in this work. Besides the widely used monomer bisphenol A, 4-tert-octylphenol (4-(1,1,3,3-tetramethylbutyl)phenol) and the technical isomer mixture of 4-nonylphenol, phenolic steroid hormones like the endogenous estrogens estrone, 17-alpha-estradiol, 17-beta-estradiol and the exogenous estrogen 17-alpha-ethinylestradiol were determined in water at the 50 - 200 picogram/L-level. Water samples from 1 L to 5 L were extracted by solid phase extraction (SPE) on a cartridge system containing LiChrolut EN as sorbent. The phenols and steroids were converted into their pentafluorbenzoylate esters in an extractive derivatisation reaction. The derivatives were then determined by high resolution gas chromatography with negative chemical ionisation mass spectrometric detection HRGC-(CH 4)-NCI-MS in the selected ion mode (SIM). All results were also confirmed by electron capture detection HRGC-ECD. This highly sensitive and specific method gives a limit of detection (LOD) of 20 pg/L for bisphenol A and 4-tert-octylphenol in drinking water samples and 50 pg/L in STW-effluent, respectively. The LODs for technical 4-nonylphenol, 17-alpha-ethinylestradiol and other estrogens are in the range of 100 pg/L in drinking water to 200 pg/L in STW-effluent, respectively. In all river water samples in Southern Germany, bisphenol A was found in concentrations ranging from 500 pg/L up to 16 ng/L, 4-nonylphenol from 6 ng/L up to 135 ng/L and the steroids from 200 pg/L up to 5 ng/L. In drinking water bisphenol A was found in concentrations ranging from 300 pg/L to 2 ng/L, 4-nonylphenol from 2 ng/L to 15 ng/L, 4-tert-octylphenol from 150 pg/L to 5 ng/L and the steroids from 100 pg/L to 2 ng/L. Mean recoveries over the whole analytical protocol, measured in bidistilled water, generally exceeded 70 %.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordHRGC-ECDdc.subject
KeywordHRGC-NCI-MSdc.subject
LCSHChemical ionization mass spectrometrydc.subject.lcsh
LCSHElectrons. Capturedc.subject.lcsh
LCSHGas chromatographydc.subject.lcsh
LCSHPhenolsdc.subject.lcsh
LCSHWater. Analysisdc.subject.lcsh
MeSHEstrogensdc.subject.mesh
TitleBestimmung von Estrogenen und endokrin aktiven Phenolen aus wässrigen Matrices im 0.1 - 100 Nanogramm/Liter-Bereichdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-68dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-8603dc.identifier.urn
GNDBisphenol Adc.subject.gnd
GNDChemische Ionisationsmassenspektrometriedc.subject.gnd
GNDElektroneneinfangdetektordc.subject.gnd
GNDEndokrin wirksamer Stoffdc.subject.gnd
GNDGaschromatographiedc.subject.gnd
GNDGC-MSdc.subject.gnd
GNDNonylphenoldc.subject.gnd
GNDÖstrogenedc.subject.gnd
GNDPhenoledc.subject.gnd
GNDWasseranalysedc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
Date of activation2001-11-26T09:14:28Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 4.999 ; W: W-H 7.103uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID860uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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