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AuthorKrämer, Lara Mariadc.contributor.author
Date of accession2018-08-03T10:34:37Zdc.date.accessioned
Available in OPARU since2018-08-03T10:34:37Zdc.date.available
Year of creation2017dc.date.created
Date of first publication2018-08-03dc.date.issued
AbstractCardiomyopathies with intracellular inclusions are a distinct subset of cardiomyopathies whereas basophilic degeneration (BD) of the heart describes inclusions in cardiomyocytes of the aging heart, which have not yet been related to a specific disease condition or to a distinct type of protein inclusion. To address the question whether BD represents a specific pathological feature and whether it is linked to a distinct disease condition we studied 62 autopsy cases. BD inclusions exhibited an immunohistochemical staining pattern related to glycosylated δ- or η-secretase N-terminal cleavage products of the amyloid precursor protein (sAPPδ/η) or shorter fragments of sAPPη. BD aggregates were found in the myocardium of both ventricles and atria with highest amounts in the atria and lowest in the interventricular septum. The frequency of BD-lesions correlated with age, arterial hypertension,myocardial fibrosis, and the severity of cerebral amyloid angiopathy (CAA). The intracytoplasmic deposition of N-terminal sAPPδ/η fragments in BD indicates a specific inclusion body pathology related to APP metabolism. The correlation with the severity of CAA, which is related to the APP-derived amyloid β-protein, supports this point of view and suggests a possible link between myocardial and cerebrovascular APP-related lesions.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordAmyloid Precursor Proteindc.subject
KeywordBasophilic degenerationdc.subject
KeywordCardiomyocytesdc.subject
KeywordMyocardial fibrosisdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHCardiomyopathiesdc.subject.mesh
MeSHHypertensiondc.subject.mesh
MeSHInclusion bodiesdc.subject.mesh
TitleInclusions of N-terminal fragments of APP in basophilic degeneration of cardiomyocytes: Pathological and clinical impactdc.title
Resource typeDissertationdc.type
Date of acceptance2018-07-13dcterms.dateAccepted
RefereeThal, Dietmardc.contributor.referee
RefereeJust, Steffendc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-8694dc.identifier.doi
PPN102916245Xdc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-8751-6dc.identifier.urn
GNDHerzmuskelkrankheitdc.subject.gnd
GNDAmyloid-Precursor-Proteindc.subject.gnd
GNDEinschlusskörperdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Innere Medizin IIuulm.affiliationSpecific
InstitutionUKU. Institut für Pathologieuulm.affiliationSpecific
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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