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AuthorKarl, Sebastiandc.contributor.author
Date of accession2018-07-26T13:11:33Zdc.date.accessioned
Available in OPARU since2018-07-26T13:11:33Zdc.date.available
Year of creation2017dc.date.created
Date of first publication2018-07-26dc.date.issued
AbstractObjective: The death of a loved one is extremely stressful, and cardiovascular risk increases nearly two-fold in the acute period of bereavement. However, no studies have attempted to intervene to reduce risk during this identifiable period. This pilot study investigated the protective effect of low-dose aspirin on cardiovascular parameters and depressed mood of bereaved participants, compared to nonbereaved healthy controls. Methods: Ten bereaved participants and 12 nonbereaved control participants had blood pressure, heart rate and heart rate variability (HRV) measured and blood drawn at a first laboratory visit. The visit was within 30 days of the death of their spouse, on average. Participants were randomized to receive low-dose aspirin (81 mg) or placebo, taken for five days. In a second laboratory visit, the same assessments were repeated, as well as a structured separation recall reactivity task (i.e., recalling a time they felt alone or abandoned). Bereaved participants recalled their bereavement experience. Results: Bereaved participants taking aspirin were more likely to report a decrease in CES-D score from the first to the second laboratory visit than those taking placebo (χ2=6.67, p<0.01, d=3.54). Levels of P-selectin (-0.12 vs. +0.16, p<0.01, d=1.22) and a composite cardiovascular risk score (-0.30 vs. +0.38, p<0.03, d=1.02) decreased more from the first to the second lab visit in participants taking aspirin. In response to the separation recall, participants taking aspirin recovered faster than those taking placebo: heart rate decreased more in the aspirin group (-2.32 vs. -5.97 beats per minute, p<0.005, d=1.64) and HRV decreased in the placebo group while it increased in the aspirin group (log RSA +0.42 vs. -0.17, p<0.03, d=1.18). Conclusions: The present pilot study was the first to measure reactivity in a bereaved population using a laboratory stress task. The results suggest that aspirin can reduce baseline cardiovascular risk markers, attenuate physiological reactivity to stressors, and ameliorate depressed mood in acutely bereaved.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordCardiovascular riskdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHBereavementdc.subject.mesh
MeSHGriefdc.subject.mesh
MeSHAspirindc.subject.mesh
MeSHDepression; Prevention and controldc.subject.mesh
MeSHHeart diseases; Prevention and controldc.subject.mesh
TitleLow-dose aspirin reduces cardiovascular baseline risk, reactivity, and depressed mood in acutely bereaveddc.title
Resource typeDissertationdc.type
Date of acceptance2018-06-14dcterms.dateAccepted
RefereeGündel, Haralddc.contributor.referee
RefereePlener, Pauldc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-8467dc.identifier.doi
PPN1028465289dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-8524-6dc.identifier.urn
GNDAcetylsalicylsäuredc.subject.gnd
GNDTrauerdc.subject.gnd
GNDDepressiondc.subject.gnd
GNDPsychische Belastungdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Klinik für Psychosomatische Medizin und Psychotherapieuulm.affiliationSpecific
InstitutionUKU. Klinik für Kinder- und Jugendpsychiatrie/Psychotherapieuulm.affiliationSpecific
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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