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Untersuchung der Funktionen der beiden switch-Regionen von RhoH bei der inhibitorischen Wirkung von RhoH in Phospholipase C-vermittelten Signalwegen

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Evelyne_Nicola.pdf (3.891Mb)
Erstveröffentlichung
2018-07-12
DOI
10.18725/OPARU-8056
Dissertation


Authors
Nicola, Evelyne
Referee
Gierschik, Peter
Mertens, Thomas
Faculties
Medizinische Fakultät
Institutions
UKU. Institut für Pharmakologie und Toxikologie
UKU. Institut für Virologie
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https://oparu.uni-ulm.de/xmlui/license_v3
Abstract
The atypical Rho-GTPase RhoH has shown altered expression in various forms of cancer. We investigated the structural conditions, especially the switch-regions, of the interaction of RhoH with Rac2, inhibiting the stimulation of the PLCγ¬2 and the PLCβ2, as well as of the suspected Rac2-independent inhibition of the PLC-enzymes by RhoH. Therefore we created different RhoH-mutants, which were subsequently expressed in Cos-7-cells together with a PLC and eventually Rac2, measuring the phosphoinositides produced by the PLC-enzymes.
Date created
2017
Subject Headings
Phospholipase C [GND]
Rho-Proteine [GND]
Type C phospholipases [MeSH]
Rho GTP-binding proteins [MeSH]
Keywords
RhoH; PLC; Rho-GTPase
Dewey Decimal Group
DDC 610 / Medicine & health

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Nicola, Evelyne (2018): Untersuchung der Funktionen der beiden switch-Regionen von RhoH bei der inhibitorischen Wirkung von RhoH in Phospholipase C-vermittelten Signalwegen. Open Access Repositorium der Universität Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-8056

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