Now showing items 1-10 of 36
Design and synthesis of submicron polymer particles for the selective capture of proteases
(Universität Ulm, 2017-03-07)
The design of biomimetic synthetic receptors capable of mimicking the molecular recognition properties of antibodies is of significant interest for the application in many analytical methods. The selective binding of ...
Development of selective sorbent materials for the determination of polychlorinated biphenyls (PCBs) in the environment
(Universität Ulm, 2016-11-21)
In this thesis, synthesis of molecularly imprinted polymers with molecular recognition for polychlorinated biphenyls (PCBs) as well as the application of the polymers as pre-concentration and clean-up sorbents in the ...
Protein aggregation during bioprocessing of monoclonal antibodies in mammalian cell culture
(Universität Ulm, 2017-02-23)
Monoclonal antibodies (mAbs) are successful biopharmaceuticals playing an important role in the treatment of cancer, autoimmunity and inflammatory diseases. Mammalian cells are the dominant system for the recombinant ...
Aggregation during biopharmaceutical production of antibodies induced by UV radiation and interface exposure
(Universität Ulm, 2017-05-05)
In the manufacturing process of therapeutic monoclonal antibodies (mAbs) aggregate formation is a crucial problem. Proteins tend to aggregate due to several stress conditions during processing and storage. This may reduce ...
Thin-film waveguide technology towards mid-infrared lab-on-chip systems
(Universität Ulm, 2017-05-12)
This cumulative thesis focuses on the development of thin-film waveguide technologies and their application for chem/bio sensors in food and feed quality monitoring scenarios. The thesis is based on seven peer-reviewed ...
Chemical and structural analysis of Xylella fastidiosa biofilm formation
(Universität Ulm, 2018-03-20)
Xylella fastidiosa (Xf) is a gram-negative phytopathogen bacterium that affects the xylem vessels of citrus, olives, grapevines, coffee, almonds among many other plants by vascular occlusion [1–3]. Diseases such as citrus ...
Towards on-chip mid-infrared sensors
(Universität Ulm, 2016-04-15)
This Feature highlights recent advances on mid-infrared thin-film waveguide technology and on-chip photonics facilitating next-generation label-free chem/bio sensor and assay platforms. Complemented by more recent advancements ...
Portable infrared laser spectroscopy for on-site mycotoxin analysis
(Universität Ulm, 2017-03-09)
Mycotoxins are toxic secondary metabolites of fungi that spoil food, and severely impact human health (e.g., causing cancer). Therefore, the rapid determination of mycotoxin contamination includingdeoxynivalenolandaflato ...
Sensing chlorinated hydrocarbons via miniaturized GaAs/AlGaAs thin-film waveguide flow cells coupled to quantum cascade lasers
(Universität Ulm, 2016-07-05)
Mid-infrared (MIR) sensors based on attenuated total reflection (ATR) spectroscopy provide robust, rapid and sensitive platforms for the detection of low levels of organic molecules and pollutants. Nowadays, MIR (3–15 μm) ...
Mid-infrared thin-film diamond waveguides combined with tunable quantum cascade lasers for analyzing the secondary structure of proteins
(Universität Ulm, 2016-04-28)
Diamond has excellent optical properties including broadband transmissivity, low self- absorption and a high refractive index, which have prompted its use in for optical sensing applications. Thin-film diamond strip ...