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AuthorWinkler, Aileendc.contributor.author
Date of accession2016-03-14T13:40:59Zdc.date.accessioned
Available in OPARU since2016-03-14T13:40:59Zdc.date.available
Year of creation2006dc.date.created
AbstractPostnatal supplementation of estradiol (E2) and progesterone (P) in preterm infants may improve lung function, possibly mediated through enhanced epithelial Na+ transport. Preterm infants of < 29 week gestational age and < 1000g birth weight needing mechanical ventilation within 12 hours of birth were randomized to receive 2,5 mg/kg E2 and 22,5 mg/kg P per day or placebo. Nasal potential difference (NPD) and amilorid-sensitive NPD (ASNPD) as amount of epithelial Na+ transport was measured in 29 infants on postnatal day of life 1, 3, 5 and 7. Mean values of all four measurements were calculated. Mean ASNPD was 6,5 ± 2,8 mV in infants receiving E2/P and 6,1 ± 2,6 mV in infants receiving placebo (not significant). NPD was -10,0 ± 3,8 mV and -10,3 ± 3,6 mV. The ASNPD was significant higher in infants surviving without bronchopulmonal dysplasia, defined as need for supplemental oxygen or mechanical ventilation at 36 weeks postmenstrual age for SaO2 90 % (7,1 ± 2,6 mV) than in infants developing BPD or dying. In conclusion, postnatal replacement of E2 and P does not change ASNPD, but infants surviving without BPD had higher ASNPD values in the first week of life.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordENaCdc.subject
KeywordNasale Potenzialdifferenzdc.subject
KeywordUntergewichtiges Neugeborenesdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHInfant, low birth weightdc.subject.mesh
TitleDer Einfluss von Östradiol und Progesteron auf die Nasenpotenzialdifferenz von Frühgeborenendc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-750dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-57937dc.identifier.urn
GNDAmiloriddc.subject.gnd
GNDBronchopulmonale Dysplasiedc.subject.gnd
GNDEstradioldc.subject.gnd
GNDFrühgeborenesdc.subject.gnd
GNDMangelgeborenesdc.subject.gnd
GNDNatriumkanaldc.subject.gnd
GNDProgesterondc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2006-12-21T12:31:19Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.328 ; W: W-H 9.438uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID5793uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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