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Der Einfluss von Östradiol und Progesteron auf die Nasenpotenzialdifferenz von Frühgeborenen

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vts_5793_7705.pdf (4.675Mb)
89 Seiten
Veröffentlichung
2006-12-21
Authors
Winkler, Aileen
Dissertation


Faculties
Medizinische Fakultät
Abstract
Postnatal supplementation of estradiol (E2) and progesterone (P) in preterm infants may improve lung function, possibly mediated through enhanced epithelial Na+ transport. Preterm infants of < 29 week gestational age and < 1000g birth weight needing mechanical ventilation within 12 hours of birth were randomized to receive 2,5 mg/kg E2 and 22,5 mg/kg P per day or placebo. Nasal potential difference (NPD) and amilorid-sensitive NPD (ASNPD) as amount of epithelial Na+ transport was measured in 29 infants on postnatal day of life 1, 3, 5 and 7. Mean values of all four measurements were calculated. Mean ASNPD was 6,5 ± 2,8 mV in infants receiving E2/P and 6,1 ± 2,6 mV in infants receiving placebo (not significant). NPD was -10,0 ± 3,8 mV and -10,3 ± 3,6 mV. The ASNPD was significant higher in infants surviving without bronchopulmonal dysplasia, defined as need for supplemental oxygen or mechanical ventilation at 36 weeks postmenstrual age for SaO2 90 % (7,1 ± 2,6 mV) than in infants developing BPD or dying. In conclusion, postnatal replacement of E2 and P does not change ASNPD, but infants surviving without BPD had higher ASNPD values in the first week of life.
Date created
2006
Subject headings
[GND]: Amilorid | Bronchopulmonale Dysplasie | Estradiol | Frühgeborenes | Mangelgeborenes | Natriumkanal | Progesteron
[MeSH]: Infant, low birth weight
[Free subject headings]: ENaC | Nasale Potenzialdifferenz | Untergewichtiges Neugeborenes
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 03.05.2003)
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-750

Winkler, Aileen (2006): Der Einfluss von Östradiol und Progesteron auf die Nasenpotenzialdifferenz von Frühgeborenen. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-750
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