Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

Erstveröffentlichung
2006
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Wissenschaftlicher Artikel


Authors
Corbacioglu, Salim
Kilic, Mehtap
Westhoff, Mike-Andrew
Reinhardt, Dirk
Fulda, Simone
et al.
Institutions
UKU. Klinik für Kinder- und Jugendmedizin
Published in
Blood ; 108 (2006), 10. - S. 3504-3513. - ISSN 0006-4971
Link to publication
https://dx.doi.org/10.1182/blood-2006-05-021691
Keywords
acute myeloid-leukemia; gastrointestinal stromal tumors; internal tandem duplication; stem-cell factor; signal-transduction; juxtamembrane domain; cancer cells; phosphatidylinositol 3-kinase; activating mutations; hematopoietic-cells
Dewey Decimal Group
DDC 610 / Medicine & health
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