Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

Corbacioglu, Salim; Kilic, Mehtap; Westhoff, Mike-Andrew; Reinhardt, Dirk; Fulda, Simone; Debatin, Klaus-Michael

Erstveröffentlichung

2006

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Wissenschaftlicher Artikel

Autoren

Corbacioglu, Salim

Kilic, Mehtap

Westhoff, Mike-Andrew

Reinhardt, Dirk

Fulda, Simone

et al.

Institutionen

UKU. Klinik für Kinder- und Jugendmedizin

Erschienen in

Blood ; 108 (2006), 10. - S. 3504-3513. - ISSN 0006-4971

Link zur Veröffentlichung

https://dx.doi.org/10.1182/blood-2006-05-021691

Schlagwörter

acute myeloid-leukemia; gastrointestinal stromal tumors; internal tandem duplication; stem-cell factor; signal-transduction; juxtamembrane domain; cancer cells; phosphatidylinositol 3-kinase; activating mutations; hematopoietic-cells

DDC-Sachgruppe

DDC 610 / Medicine & health

Metadata

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