Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

Gonzalez, P.; Mader, I.; Tchoghandjian, A.; Enzenmüller, Stefanie; Cristofanon, S.; Basit, F.; Debatin, Klaus-Michael; Fulda, S.

Erstveröffentlichung

2012

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Wissenschaftlicher Artikel

Authors

Gonzalez, P.

Mader, I.

Tchoghandjian, A.

Enzenmüller, Stefanie

Cristofanon, S.

et al.

Institutions

UKU. Klinik für Kinder- und Jugendmedizin

Published in

Cell Death and Differentiation ; 19 (2012), 8. - S. 1337-1346. - ISSN 1350-9047

Link to publication

https://dx.doi.org/10.1038/cdd.2012.10

Keywords

betulinic acid; apoptosis; autophagy; lysosomes; induced apoptosis; glioma-cells; inhibition; caspases; cancer; macroautophagy; sensitivity; activation; expression; proteases

Dewey Decimal Group

DDC 610 / Medicine & health

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