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AutorKleinJan, Fennekedc.contributor.author
Aufnahmedatum2018-04-09T09:42:55Zdc.date.accessioned
In OPARU verfügbar seit2018-04-09T09:42:55Zdc.date.available
Jahr der Erstellung2017dc.date.created
Datum der Erstveröffentlichung2018-04-09dc.date.issued
ZusammenfassungThe viscoelasticity of the cell's cytoskeleton is important for various cellular processes and changes in these properties are associated with numerous diseases. Microrheology, which uses the motion of embedded particles, was used to study these properties of the extracted cytoskeleton network of 3T3 fibroblasts, alveolar epithelial cells (A549 and R3/1) and kidney fibroblasts expressing the integrins avb3 and/or a5b1. Using centroid dedrifting and offset fitting to reduce drift and the static error, video particle tracking microrheology could be used up to kHz frequencies. The obtained persistence length of filaments in the cytoskeletal network suggested that the network surrounding the tracer particles consisted mostly of intermediate filaments, which could be best described by the glassy worm-like chain model. Characterizing the response of the cytoskeletal filament network to mechanical stimuli showed that it was cell type and integrin type dependent.dc.description.abstract
Spracheendc.language.iso
Verbreitende StelleUniversität Ulmdc.publisher
LizenzStandarddc.rights
Link zum Lizenztexthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
SchlagwortCell mechanicsdc.subject
SchlagwortPassive microrheologydc.subject
SchlagwortSemiflexible polymersdc.subject
DDC-SachgruppeDDC 530 / Physicsdc.subject.ddc
LCSHCells; Mechanical porpertiesdc.subject.lcsh
LCSHCytoskeletondc.subject.lcsh
LCSHIntegrinsdc.subject.lcsh
LCSHPolymers; Rheologydc.subject.lcsh
LCSHIntermediate filament proteinsdc.subject.lcsh
TitelViscoelastic and structural properties of the cytoskeletondc.title
RessourcentypDissertationdc.type
Datum der Annahme2018-02-01dcterms.dateAccepted
GutachterGottschalk, Kay-Eberharddc.contributor.referee
GutachterWalther, Pauldc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-5904dc.identifier.doi
PPN505486377dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-5961-1dc.identifier.urn
GNDZellskelettdc.subject.gnd
GNDMikrorheologiedc.subject.gnd
GNDIntermediärfilamentdc.subject.gnd
GNDSemiflexible Polymeredc.subject.gnd
FakultätFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Experimentelle Physikuulm.affiliationSpecific
InstitutionZE Elektronenmikroskopieuulm.affiliationSpecific
Titelverleihende FakultätFakultät für Naturwissenschaftenuulm.thesisGrantor
DCMI MedientypTextuulm.typeDCMI
KategoriePublikationenuulm.category


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