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AuthorKleinJan, Fennekedc.contributor.author
Date of accession2018-04-09T09:42:55Zdc.date.accessioned
Available in OPARU since2018-04-09T09:42:55Zdc.date.available
Year of creation2017dc.date.created
Date of first publication2018-04-09dc.date.issued
AbstractThe viscoelasticity of the cell's cytoskeleton is important for various cellular processes and changes in these properties are associated with numerous diseases. Microrheology, which uses the motion of embedded particles, was used to study these properties of the extracted cytoskeleton network of 3T3 fibroblasts, alveolar epithelial cells (A549 and R3/1) and kidney fibroblasts expressing the integrins avb3 and/or a5b1. Using centroid dedrifting and offset fitting to reduce drift and the static error, video particle tracking microrheology could be used up to kHz frequencies. The obtained persistence length of filaments in the cytoskeletal network suggested that the network surrounding the tracer particles consisted mostly of intermediate filaments, which could be best described by the glassy worm-like chain model. Characterizing the response of the cytoskeletal filament network to mechanical stimuli showed that it was cell type and integrin type dependent.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordCell mechanicsdc.subject
KeywordPassive microrheologydc.subject
KeywordSemiflexible polymersdc.subject
Dewey Decimal GroupDDC 530 / Physicsdc.subject.ddc
LCSHCells; Mechanical porpertiesdc.subject.lcsh
LCSHCytoskeletondc.subject.lcsh
LCSHIntegrinsdc.subject.lcsh
LCSHPolymers; Rheologydc.subject.lcsh
LCSHIntermediate filament proteinsdc.subject.lcsh
TitleViscoelastic and structural properties of the cytoskeletondc.title
Resource typeDissertationdc.type
Date of acceptance2018-02-01dcterms.dateAccepted
RefereeGottschalk, Kay-Eberharddc.contributor.referee
RefereeWalther, Pauldc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-5904dc.identifier.doi
PPN1023681439dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-5961-1dc.identifier.urn
GNDZellskelettdc.subject.gnd
GNDMikrorheologiedc.subject.gnd
GNDIntermediärfilamentdc.subject.gnd
GNDSemiflexible Polymeredc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Experimentelle Physikuulm.affiliationSpecific
InstitutionZE Elektronenmikroskopieuulm.affiliationSpecific
Grantor of degreeFakultät für Naturwissenschaftenuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category


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