Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Li, Sheng; Garrett-Bakelman, Francine E.; Chung, Stephen S.; Sanders, Mathijs A.; Hricik, Todd; Rapaport, Franck; Patel, Jay; Dillon, Richard; Vijay, Priyanka; Brown, Anna L.; Perl, Alexander E.; Cannon, Joy; Bullinger, Lars; Luger, Selina; Becker, Michael; Lewis, Ian D.; To, Luen Bik; Delwel, Ruud; Lowenberg, Bob; Döhner, Hartmut; Guzman, Monica L.; Hassane, Duane C.; Roboz, Gail J.; Grimwade, David; Valk, Peter J. M.; D'Andrea, Richard J.; Carroll, Martin; Park, Christopher Y.; Neuberg, Donna; Levine, Ross; Melnick, Ari M.; Mason, Christopher E.

Erstveröffentlichung

2016

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Wissenschaftlicher Artikel

Authors

Li, Sheng

Garrett-Bakelman, Francine E.

Chung, Stephen S.

Sanders, Mathijs A.

Hricik, Todd

et al.

Institutions

UKU. Klinik für Innere Medizin III

Published in

Nature Medicine ; 22 (2016), 7. - S. 792-799. - ISSN 1078-8956. - eISSN 1546-170X

Link to publication

https://dx.doi.org/10.1038/nm.4125

Funding information

Starr Cancer Consortium [I4-A442, I7-A765, I9-A9-071]
Irma T. Hirschl Charitable Trust
Monique Weill-Caulier Charitable Trust
Bert L. and N. Kuggie Vallee Foundation
WorldQuant Foundation
etc.

Keywords

chronic lymphocytic-leukemia; clonal evolution; dna methylation; mutations result; tet2 function; cancer; differentiation; chemotherapy; malignancies; progression

Dewey Decimal Group

DDC 610 / Medicine & health

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