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Tracking disease progression in Huntington’s Disease using electrophysiology of the sensorimotor system

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Erstveröffentlichung
2018-02-01
DOI
10.18725/OPARU-5383

Dissertation

Autoren
Mayer, Isabella Maria Sophie
Gutachter
Orth, Michael
Kammer, Thomas
Fakultäten
Medizinische Fakultät
Institutionen
UKU. Klinik für Neurologie
Lizenz
Standard
https://oparu.uni-ulm.de/xmlui/license_v3
Zusammenfassung
Huntington’s Disease (HD) is a hereditary progressive neurodegenerative disorder with pathologies occurring on structural, functional and behavioral levels in the course of the disease. Since visible symptoms only begin to occur in mid-adulthood, being able to predict motor symptom onset would be valuable for clinical use. We found that over the 24-month observation period, our HD gene carrier groups had a stronger deterioration in somatosensory evoked potential (SEP) amplitude than healthy controls. Within the HD gene carriers, the converter group, experiencing motor symptom onset during the study, showed a steeper deterioration than the early manifest group and tended towards having a steeper decline than premanifest group. Groups were similar in regards to their latencies, motor thresholds and motor evoked potentials (MEPs). When comparing slopes intraindividually in the converter group, we were able to show that SEP deterioration was steeper around symptom onset than it was in a comparable timeframe before or after onset. Even though these results indicate that SEPs are sensitive for tracking disease progression inter- and intraindividually, we were unable to predict motor symptom onset from the N20 slope. This indicates that sensory afferent pathways might be more precise to track development than motor efferent pathways.
Erstellung / Fertigstellung
2017
Normierte Schlagwörter
Huntington-Chorea [GND]
Längsschnittuntersuchung [GND]
Transkranielle magnetische Stimulation [GND]
Huntington disease [MeSH]
Transcranial magnetic stimulation [MeSH]
Longitudinal studies [MeSH]
Schlagwörter
Sensory evoked potentials; Sensorimotor System
DDC-Sachgruppe
DDC 610 / Medicine & health

Metadata
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Zitiervorlage

Mayer, Isabella Maria Sophie (2018): Tracking disease progression in Huntington’s Disease using electrophysiology of the sensorimotor system. Open Access Repositorium der Universität Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-5383

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