The association between treatment modality, lipid profile, ,metabolic control in children with type 1 diabetes and celiac disease—data from the international sweet registry
peer-reviewed
Erstveröffentlichung
2021-12-15Authors
Marino, Monica
Eckert, Alexander J.
Tell, Shoshana
Krnic, Nevena
Deja, Grazyna
Editor
Fernandez, Maria LuzGarg, Manohar
Wissenschaftlicher Artikel
Published in
Nutrients ; 13 (2021), 12. - Art.-Nr. 4473. - eISSN 2072-6643
Link to original publication
https://dx.doi.org/10.3390/nu13124473Faculties
Medizinische FakultätInstitutions
Institut für Epidemiologie und Medizinische BiometrieZentralinstitut für Biomedizinische Technik (ZIBMT)
Document version
published version (publisher's PDF)Abstract
Background and Aims: A higher frequency of dyslipidemia is reported in children with type 1 diabetes (T1D) and celiac disease (CD). Recently, continuous subcutaneous insulin infusion (CSII) has been associated with better lipid profiles in patients with T1D. The aim of this study was to investigate the association between treatment modality and lipid profile, metabolic control, and body mass index (BMI)-SDS in children with both T1D and CD. Methods: Cross-sectional study in children registered in the international SWEET database in November 2020. Inclusion criteria were children (2–18 years) with T1D and CD with available data on treatment modality (CSII and injections therapy, IT), triglyceride, total cholesterol, HDL, LDL, dyslipidemia, HbA1c, and BMI-SDS. Overweight/obesity was defined as > +1 BMI-SDS for age. Data were analyzed by linear and logistical regression models with adjustment for age, gender, and diabetes duration. Results: In total 1009 children with T1D and CD (female 54%, CSII 54%, age 13.9 years ±3.6, diabetes duration 7.2 years ±4.1, HbA1c 7.9% ±1.4) were included. Significant differences between children treated with CSII vs. IT were respectively found; HDL 60.0 mg/dL vs. 57.8 mg/dL, LDL 89.4 mg/dL vs. 94.2 mg/dL, HbA1c 7.7 vs. 8.1%, BMI-SDS 0.4 vs. 0.6, overweight and obesity 17% vs. 26% (all p < 0.05). Conclusions: CSII is associated with higher HDL and lower LDL, HbA1c, BMI-SDS, and percentage of overweight and obesity compared with IT in this study. Further prospective studies are required to determine whether CSII improves lipid profile, metabolic control and normalize body weight in children with both T1D and CD.
Subject headings
[GND]: Diabetes mellitus Typ 1 | Zöliakie | Blutzucker | Insulin | Infusion[MeSH]: Diabetes mellitus, Type 1; Drug therapy | Celiac disease | Insulin infusion systems | Glycemic control
[Free subject headings]: type 1 diabetes | continuous subcutaneous insulin infusion | lipid profile
[DDC subject group]: DDC 610 / Medicine & health
Metadata
Show full item recordDOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-50325
Marino, Monica et al. (2023): The association between treatment modality, lipid profile, ,metabolic control in children with type 1 diabetes and celiac disease—data from the international sweet registry. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-50325
Citation formatter >