An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia

Gruber, Tanja A.; Gedman, Amanda Larson; Zhang, Jinghui; Koss, Cary S.; Marada, Suresh; Ta, Huy Q.; Chen, Shann-Ching; Su, Xiaoping; Ogden, Stacey K.; Dang, Jinjun; Wu, Gang; Gupta, Vedant; Andersson, Anna K.; Pounds, Stanley; Shi, Lei; Easton, John; Barbato, Michael I.; Mulder, Heather L.; Manne, Jayanthi; Wang, Jianmin; Rusch, Michael; Ranade, Swati; Ganti, Ramapriya; Parker, Matthew; Ma, Jing; Radtke, Ina; Ding, Li; Cazzaniga, Giovanni; Biondi, Andrea; Kornblau, Steven M.; Ravandi, Farhad; Kantarjian, Hagop; Ninner, Stephen D.; Doehner, Konstanze; Döhner, Hartmut; Ley, Timothy J.; Ballerini, Paola; Shurtleff, Sheila; Tomizawa, Daisuke; Adachi, Souichi; Hayashi, Yasuhide; Tawa, Akio; Shih, Lee-Yung; Liang, Der-Cherng; Rubnitz, Jeffrey E.; Pui, Ching-Hon; Mardis, Elaine R.; Wilson, Richard K.; Downing, James R.

Erstveröffentlichung

2012

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Wissenschaftlicher Artikel

Authors

Gruber, Tanja A.

Gedman, Amanda Larson

Zhang, Jinghui

Koss, Cary S.

Marada, Suresh

et al.

Institutions

UKU. Klinik für Innere Medizin III

Published in

Cancer Cell ; 22 (2012), 5. - S. 683-697. - ISSN 1535-6108

Link to publication

https://dx.doi.org/10.1016/j.ccr.2012.10.007

Funding information

National Institutes of Health (Cancer Center Support Grant) [P30 CA021765]
Eric Trump Foundation
Leukemia & Lymphoma Society Specialized Center of Research Grant [LLS7015]
American Lebanese Syrian Associated Charities (ALSAC) of St Jude Children's Research Hospital

Keywords

acute megakaryocytic leukemia; acute myeloid-leukemia; acute lymphoblastic-leukemia; zinc-finger protein; oncology-group; functional-characterization; genetic alterations; gli proteins; cell-line; differentiation

Dewey Decimal Group

DDC 610 / Medicine & health

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