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AuthorLohmann, Peterdc.contributor.author
Date of accession2016-03-14T13:39:31Zdc.date.accessioned
Available in OPARU since2016-03-14T13:39:31Zdc.date.available
Year of creation2006dc.date.created
AbstractImpairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer’s disease (AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse model of AD. We also assessed brain content of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). Performance was alike in wild-type and APP23 animals in the radial maze. In contrast, performance in the complex maze was better in wild-type than APP23 animals. Contrary to the wild-type, hippocampal BDNF levels decreased on training in APP23 animals. Hippocampal and frontal cortex NGF levels in APP23 animals correlated with the time to solve the complex maze, but correlated inversely with escape time in wild-type animals. NT-3 levels were alike in wild-type and APP23 animals and were unchanged even after training. Both types of mazes depend on hippocampal integrity to some extent. However, according to the cognitive mapping theory of spatial learning the complex maze due to the increased complexity of the environment most likely depends stronger on preserved hippocampal function than the radial maze in the working memory configuration applied here. Greater impairment in complex maze performance than in radial maze performance thus resembles the predominant affliction of the loss of hippocampal function in human AD. NGF- and BDNF-levels on maze learning are different in wild-type and transgenic animals, indicating that biological markers of AD may be altered on challenge even though equilibrium levels are alike.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
Keyword3-NPAdc.subject
KeywordF1-Generationdc.subject
KeywordKomplex-Labyrinthdc.subject
KeywordRadial-Labyrinthdc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
LCSHMicedc.subject.lcsh
TitleUntersuchung der räumlichen Orientierung bei Mäusen in einem neuartigen komplexen Labyrinth: Paradigmen, biochemische und neurophysiologische Korrelatedc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-469dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56865dc.identifier.urn
GNDAlzheimer-Krankheitdc.subject.gnd
GNDLangzeitpotenzierungdc.subject.gnd
GNDLernendc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
Date of activation2006-08-22T19:54:43Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.241 ; W: W-H 9.355uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID5686uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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