| Author | Nalapareddy, Kodandaramireddy | dc.contributor.author |
| Author | Nattamai, Kalpana J. | dc.contributor.author |
| Author | Kumar, Rupali S. | dc.contributor.author |
| Author | Karns, Rebekah | dc.contributor.author |
| Author | Wikenheiser-Brokamp, Kathryn A. | dc.contributor.author |
| Author | Sampson, Leesa L. | dc.contributor.author |
| Author | Mahe, Maxime M. | dc.contributor.author |
| Author | Sundaram, Nambirajan | dc.contributor.author |
| Author | Yacyshyn, Mary-Beth | dc.contributor.author |
| Author | Yacyshyn, Bruce | dc.contributor.author |
| Author | Helmrath, Michael A. | dc.contributor.author |
| Author | Zheng, Yi | dc.contributor.author |
| Author | Geiger, Hartmut | dc.contributor.author |
| Date of accession | 2023-06-07T13:21:28Z | dc.date.accessioned |
| Available in OPARU since | 2023-06-07T13:21:28Z | dc.date.available |
| Date of first publication | 2017-03-14 | dc.date.issued |
| Abstract | Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, and cell composition upon aging. Second, we identify a decline in the regenerative capacity of ISCs upon aging because of a decline in canonical Wnt signaling in ISCs. Changes in expression of Wnts are found in stem cells themselves and in their niche, including Paneth cells and mesenchyme. Third, reactivating canonical Wnt signaling enhances the function of both murine and human ISCs and, thus, ameliorates aging-associated phenotypes of ISCs in an organoid assay. Our data demonstrate a role for impaired Wnt signaling in physiological aging of ISCs and further identify potential therapeutic avenues to improve ISC regenerative potential upon aging. | dc.description.abstract |
| Language | en | dc.language.iso |
| Publisher | Universität Ulm | dc.publisher |
| License | CC BY-NC-ND 4.0 International | dc.rights |
| Link to license text | https://creativecommons.org/licenses/by-nc-nd/4.0/ | dc.rights.uri |
| Keyword | telomere dysfunction | dc.subject |
| Keyword | crypts | dc.subject |
| Keyword | niche | dc.subject |
| Keyword | epithelium | dc.subject |
| Keyword | marker | dc.subject |
| Keyword | intestinal stem cells | dc.subject |
| Keyword | Wnt signaling | dc.subject |
| Dewey Decimal Group | DDC 570 / Life sciences | dc.subject.ddc |
| Dewey Decimal Group | DDC 610 / Medicine & health | dc.subject.ddc |
| LCSH | Cancer | dc.subject.lcsh |
| MeSH | Stem cells | dc.subject.mesh |
| MeSH | Intestinal mucosa; Cytology | dc.subject.mesh |
| MeSH | Wnt signaling pathway | dc.subject.mesh |
| MeSH | Aging | dc.subject.mesh |
| MeSH | Neoplasms | dc.subject.mesh |
| MeSH | Regeneration | dc.subject.mesh |
| MeSH | Homeostasis | dc.subject.mesh |
| MeSH | Telomere | dc.subject.mesh |
| MeSH | Receptors, Notch | dc.subject.mesh |
| Title | Canonical Wnt signaling ameliorates aging of intestinal stem cells | dc.title |
| Resource type | Wissenschaftlicher Artikel | dc.type |
| Version | publishedVersion | dc.description.version |
| DOI | http://dx.doi.org/10.18725/OPARU-49023 | dc.identifier.doi |
| URN | http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-49099-4 | dc.identifier.urn |
| GND | Altern | dc.subject.gnd |
| GND | Krebs <Medizin> | dc.subject.gnd |
| GND | Stammzelle | dc.subject.gnd |
| GND | Telomer <Molekulargenetik> | dc.subject.gnd |
| GND | Homöostase | dc.subject.gnd |
| GND | Regeneration | dc.subject.gnd |
| Institution | Zentralinstitut für Biomedizinische Technik (ZIBMT) | uulm.affiliationSpecific |
| Institution | Zentrum für Alternsforschung (arc uulm) | uulm.affiliationSpecific |
| Peer review | ja | uulm.peerReview |
| DCMI Type | Text | uulm.typeDCMI |
| Category | Publikationen | uulm.category |
| DOI of original publication | 10.1016/j.celrep.2017.02.056 | dc.relation1.doi |
| Source - Title of source | Cell Reports | source.title |
| Source - Place of publication | Cell Press | source.publisher |
| Source - Volume | 18 | source.volume |
| Source - Issue | 11 | source.issue |
| Source - Year | 2017 | source.year |
| Source - From page | 2608 | source.fromPage |
| Source - To page | 2621 | source.toPage |
| Source - ISSN | 2211-1247 | source.identifier.issn |
| Community | Zentrale Einrichtungen | uulm.community |
| WoS | 000397330000008 | uulm.identifier.wos |
| Bibliography | uulm | uulm.bibliographie |
| Is Supplemented By | https://ars.els-cdn.com/content/image/1-s2.0-S2211124717302541-mmc1.pdf | dc.relation.isSupplementedBy |
| Is Supplemented By | https://ars.els-cdn.com/content/image/1-s2.0-S2211124717302541-mmc2.pdf | dc.relation.isSupplementedBy |
| Project uulm | Lineage Determination and Tissue HomeOstasis in the aged Hematopoietic System / NIH / AG040118 | uulm.projectOther |
