Thoracic trauma promotes alpha-Synuclein oligomerization in murine Parkinson's disease

peer-reviewed
Erstveröffentlichung
2022-09-24Authors
Ruf, Wolfgang P.
Palmer, Annette
Dörfer, Lena
Wiesner, Diana
Buck, Eva
Wissenschaftlicher Artikel
Published in
Neurobiology of Disease ; 174 (2022). - Art.-Nr. 105877. - ISSN 0969-9961. - eISSN 1095-953X
Link to original publication
https://dx.doi.org/10.1016/j.nbd.2022.105877Faculties
Medizinische FakultätInstitutions
UKU. Klinik für NeurologieUKU. Institut für Klinische und Experimentelle Trauma-Immunologie
Document version
published version (publisher's PDF)Abstract
Background
Systemic and neuroinflammatory processes play key roles in neurodegenerative diseases such as Parkinson's disease (PD). Physical trauma which induces considerable systemic inflammatory responses, represents an evident environmental factor in aging. However, little is known about the impact of physical trauma, on the immuno-pathophysiology of PD. Especially blunt chest trauma which is associated with a high morbidity and mortality rate in the elderly population, can induce a strong pulmonary and systemic inflammatory reaction. Hence, we sought out to combine a well-established thoracic trauma mouse model with a well-established PD mouse model to characterize the influence of physical trauma to neurodegenerative processes in PD.
Methods
To study the influence of peripheral trauma in a PD mouse model we performed a highly standardized blunt thorax trauma in a well-established PD mouse model and determined the subsequent local and systemic response.
Results
We could show that blunt chest trauma leads to a systemic inflammatory response which is quantifiable with increased inflammatory markers in bronchoalveolar fluids (BALF) and plasma regardless of the presence of a PD phenotype. A difference of the local inflammatory response in the brain between the PD group and non-PD group could be detected, as well as an increase in the formation of oligomeric pathological alpha-Synuclein (asyn) suggesting an interplay between peripheral thoracic trauma and asyn pathology in PD.
Conclusion
Taken together this study provides evidence that physical trauma is associated with increased asyn oligomerization in a PD mouse model underlining the relevance of PD pathogenesis under traumatic settings.
DFG Project THU
SFB 1149 / Gefahrenantwort, Störfaktoren und regeneratives Potential nach akutem Trauma / DFG / 251293561
GRK 1789 / CEMMA / Zelluläre und molekulare Mechanismen der Alterung / DFG / 194266605
Initiation und Propagation von alpha-Synuclein-Oligomeren --Relevanz für die Parkinson-Erkrankung / DFG / Emmy Noether-Nachwuchsgruppen / 282604822 [DA 1657/2-1]
GRK 1789 / CEMMA / Zelluläre und molekulare Mechanismen der Alterung / DFG / 194266605
Initiation und Propagation von alpha-Synuclein-Oligomeren --Relevanz für die Parkinson-Erkrankung / DFG / Emmy Noether-Nachwuchsgruppen / 282604822 [DA 1657/2-1]
Subject headings
[GND]: Parkinson-Krankheit | Entzündung | Trauma | Lungenverletzung | Schädel-Hirn-Trauma | Synuclein <alpha-> | Mikroglia | Stress[MeSH]: Parkinson disease | Lung injury | Craniocerebral trauma | Microglia | Inflammation | alpha-Synuclein
[Free subject headings]: Parkinson's disease | Peripheral lesion | Dendritic spines | Head injury | Expression | Model | Risk
[DDC subject group]: DDC 570 / Life sciences | DDC 610 / Medicine & health
Metadata
Show full item recordDOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-48927
Ruf, Wolfgang P. et al. (2023): Thoracic trauma promotes alpha-Synuclein oligomerization in murine Parkinson's disease. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-48927
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