Autonomous ultrafast self-healing hydrogels by pH-responsive functional nanofiber gelators as cell matrices
peer-reviewed
Erstveröffentlichung
2018-11-09Authors
Gačanin, Jasmina
Hedrich, Jana
Sieste, Stefanie
Glasser, Gunnar
Lieberwirth, Ingo
Wissenschaftlicher Artikel
Published in
Advanced Materials ; 31 (2019), 2. - Art.-Nr. 1805044. - ISSN 0935-9648. - eISSN 1521-4095
Link to original publication
https://dx.doi.org/10.1002/adma.201805044Faculties
Fakultät für NaturwissenschaftenMedizinische Fakultät
Institutions
Institut für Anorganische Chemie I (Materialien und Katalyse)UKU. Institut für Pharmakologie und Toxikologie
Institut für Physiologische Chemie
Document version
published version (publisher's PDF)Abstract
The synthesis of hybrid hydrogels by pH-controlled structural transition with exceptional rheological properties as cellular matrix is reported. “Depsi” peptide sequences are grafted onto a polypeptide backbone that undergo a pH-induced intramolecular O–N–acyl migration at physiological conditions affording peptide nanofibers (PNFs) as supramolecular gelators. The polypeptide–PNF hydrogels are mechanically remarkably robust. They reveal exciting thixotropic behavior with immediate in situ recovery after exposure to various high strains over long periods and self-repair of defects by instantaneous reassembly. High cytocompatibility, convenient functionalization by coassembly, and controlled enzymatic degradation but stability in 2D and 3D cell culture as demonstrated by the encapsulation of primary human umbilical vein endothelial cells and neuronal cells open many attractive opportunities for 3D tissue engineering and other biomedical applications.
EU Project uulm
AD-gut / Alzheimer Disease - gut connection / EC / H2020 / 686271
DFG Project THU
SFB 1149 Teilprojekt A04 / Zelltypspezifische Trägerproteine für die gezielte pharmakologische Hemmung der Rho-/Aktin-abhängigen Leukozyten-Rekrutierung in den Alveolarraum nach stumpfem Thoraxtrauma / DFG / 251293561
Identification and functional characterization of novel nanofiber-growth factor hybrid molecules for regeneration in a mouse traumatic brain injury model / DFG / 441734479 [KN543/6]
Identification and functional characterization of novel nanofiber-growth factor hybrid molecules for regeneration in a mouse traumatic brain injury model / DFG / 441734479 [KN543/6]
Project uulm
Self-assembling peptides as potent cell-type specific enhancers of retroviral gene transfer (extension) / Volkswagenstiftung / 89943
Is supplemented by
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadma.201805044&file=adma201805044-sup-0001-S1.pdfSubject headings
[GND]: Zellkultur | Hydrogel | Thixotropie[LCSH]: Cell culture | Colloids | Thixotropy
[Free subject headings]: cell cultivation | depsi peptide | hydrogels | peptide nanofibers
[DDC subject group]: DDC 530 / Physics | DDC 540 / Chemistry & allied sciences | DDC 620 / Engineering & allied operations
Metadata
Show full item recordDOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-48926
Gačanin, Jasmina et al. (2023): Autonomous ultrafast self-healing hydrogels by pH-responsive functional nanofiber gelators as cell matrices. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-48926
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