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AuthorFleischer, Ramonadc.contributor.author
AuthorSchmid, Dominik W.dc.contributor.author
AuthorWasimuddin,dc.contributor.author
AuthorBrändel, Stefan D.dc.contributor.author
AuthorRasche, Andreadc.contributor.author
AuthorCorman, Victor M.dc.contributor.author
AuthorDrosten, Christiandc.contributor.author
AuthorTschapka, Marcodc.contributor.author
AuthorSommer, Simonedc.contributor.author
Date of accession2023-06-05T11:48:30Zdc.date.accessioned
Available in OPARU since2023-06-05T11:48:30Zdc.date.available
Date of first publication2022-05-16dc.date.issued
AbstractAbstract Astroviruses (AstVs) infect numerous mammalian species including reservoirs such as bats. Peptides encoded by the genes of the highly polymorphic Major Histocompatibility Complex (MHC) form the first line of host defence against pathogens. Aside from direct involvement in mounting adaptive immune responses, MHC class II genes are hypothesized to regulate gut commensal diversity and shape the production of immune‐modulatory substances by microbes, indirectly affecting host susceptibility. Despite initial empirical evidence for the link between host MHC and the microbiota, associations among these factors remain largely unknown. To fill this gap, we examined MHC allelic diversity and constitution, the gut bacterial community and abundance pattern of a wild population of a neotropical bat (Artibeus jamaicensis) challenged by AstV infections. First, we show an age‐dependent relationship between the host MHC class II diversity and constitution and the gut microbiota in AstV‐uninfected bats. Crucially, these associations changed in AstV‐infected bats. Additionally, we identify changes in the abundance of specific bacterial taxa linked to the presence of certain MHC supertypes and AstV infection. We suggest changes in the microbiota to be either a result of AstV infection or the MHC‐mediated modulation of microbial communities. The latter could subsequently affect microbe‐mediated immunity and resistance against AstV infection. Our results emphasize that the reciprocal nature of host immune genetics, gut microbial diversity and pathogen infection require attention, which are particularly important given their repercussions for disease susceptibility and severity in wild animal populations with a history of zoonotic spillover and frequent human contact.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordastrovirus infectiondc.subject
Keywordgut microbiomedc.subject
Keywordzoonosisdc.subject
Dewey Decimal GroupDDC 570 / Life sciencesdc.subject.ddc
LCSHArtibeus jamaicensisdc.subject.lcsh
LCSHImmunitydc.subject.lcsh
MeSHMajor Histocompatibility Complexdc.subject.mesh
TitleInteraction between MHC diversity and constitution, gut microbiota and astrovirus infections in a neotropical batdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2022-09-21T21:01:55Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-48923dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-48999-9dc.identifier.urn
GNDImmunität (Medizin)dc.subject.gnd
GNDMHCdc.subject.gnd
GNDZoonosedc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Evolutionsökologie und Naturschutzgenomikuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.1111/mec.16491dc.relation1.doi
Source - Title of sourceMolecular Ecologysource.title
Source - Place of publicationWileysource.publisher
Source - Volume31source.volume
Source - Issue12source.issue
Source - Year2022source.year
Source - From page3342source.fromPage
Source - To page3359source.toPage
Source - ISSN0962-1083source.identifier.issn
Source - eISSN1365-294Xsource.identifier.eissn
WoS000796267300001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fmec.16491&file=mec16491-sup-0001-AppendixS1.docxdc.relation.isSupplementedBy
DFG project uulmSPP 1596 Teilprojekt / Prozesse und Mechanismen der Zunahme und Diversifizierung von Viren im Wildtierreservoir: Integration von Wirts- und Virusmerkmalen in Landschaften unterschiedlicher anthropogener Störung / DFG / 226351195 [SO 428/9-1, SO 428/9-2, TS 81/7-1, TS 81/7-2]uulm.projectDFG


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