Interaction between MHC diversity and constitution, gut microbiota and astrovirus infections in a neotropical bat
peer-reviewed
Erstveröffentlichung
2022-05-16Authors
Fleischer, Ramona
Schmid, Dominik W.
Wasimuddin,
Brändel, Stefan D.
Rasche, Andrea
Wissenschaftlicher Artikel
Published in
Molecular Ecology ; 31 (2022), 12. - S. 3342-3359. - ISSN 0962-1083. - eISSN 1365-294X
Link to original publication
https://dx.doi.org/10.1111/mec.16491Faculties
Fakultät für NaturwissenschaftenInstitutions
Institut für Evolutionsökologie und NaturschutzgenomikDocument version
published version (publisher's PDF)Abstract
Abstract
Astroviruses (AstVs) infect numerous mammalian species including reservoirs such as bats. Peptides encoded by the genes of the highly polymorphic Major Histocompatibility Complex (MHC) form the first line of host defence against pathogens. Aside from direct involvement in mounting adaptive immune responses, MHC class II genes are hypothesized to regulate gut commensal diversity and shape the production of immune‐modulatory substances by microbes, indirectly affecting host susceptibility. Despite initial empirical evidence for the link between host MHC and the microbiota, associations among these factors remain largely unknown. To fill this gap, we examined MHC allelic diversity and constitution, the gut bacterial community and abundance pattern of a wild population of a neotropical bat (Artibeus jamaicensis) challenged by AstV infections. First, we show an age‐dependent relationship between the host MHC class II diversity and constitution and the gut microbiota in AstV‐uninfected bats. Crucially, these associations changed in AstV‐infected bats. Additionally, we identify changes in the abundance of specific bacterial taxa linked to the presence of certain MHC supertypes and AstV infection. We suggest changes in the microbiota to be either a result of AstV infection or the MHC‐mediated modulation of microbial communities. The latter could subsequently affect microbe‐mediated immunity and resistance against AstV infection. Our results emphasize that the reciprocal nature of host immune genetics, gut microbial diversity and pathogen infection require attention, which are particularly important given their repercussions for disease susceptibility and severity in wild animal populations with a history of zoonotic spillover and frequent human contact.
DFG Project THU
SPP 1596 Teilprojekt / Prozesse und Mechanismen der Zunahme und Diversifizierung von Viren im Wildtierreservoir: Integration von Wirts- und Virusmerkmalen in Landschaften unterschiedlicher anthropogener Störung / DFG / 226351195 [SO 428/9-1, SO 428/9-2, TS 81/7-1, TS 81/7-2]
Is supplemented by
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fmec.16491&file=mec16491-sup-0001-AppendixS1.docxSubject headings
[GND]: Immunität (Medizin) | MHC | Zoonose[LCSH]: Artibeus jamaicensis | Immunity
[MeSH]: Major Histocompatibility Complex
[Free subject headings]: astrovirus infection | gut microbiome | zoonosis
[DDC subject group]: DDC 570 / Life sciences
Metadata
Show full item recordDOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-48923
Fleischer, Ramona et al. (2023): Interaction between MHC diversity and constitution, gut microbiota and astrovirus infections in a neotropical bat. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. http://dx.doi.org/10.18725/OPARU-48923
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