Gender-, age- and region-specific characterization of vertebral bone microstructure through automated segmentation and 3D texture analysis of routine abdominal CT
El Husseini, Malek
Löffler, Maximilian T.
Frontiers in Endocrinology ; 12 (2022). - Art.-Nr. 792760. - eISSN 1664-2392
Link to original publicationhttps://dx.doi.org/10.3389/fendo.2021.792760
InstitutionsUKU. Klinik für diagnostische und interventionelle Radiologie
External cooperationsTechnische Universität München
Singapore University of Technology and Design
Changi General Hospital
Document versionpublished version (publisher's PDF)
Purpose To identify long-term reproducible texture features (TFs) of spinal computed tomography (CT), and characterize variations with regard to gender, age and vertebral level using our automated quantification framework. Methods We performed texture analysis (TA) on baseline and follow-up CT (follow-up duration: 30–90 days) of 21 subjects (8 females, 13 males, age at baseline 61.2 ± 9.2 years) to determine long-term reproducibility. TFs with a long-term reproducibility error Δrel<5% were further analyzed for an association with age and vertebral level in a cohort of 376 patients (129 females, 247 males, age 62.5 ± 9.2 years). Automated analysis comprised labeling and segmentation of vertebrae into subregions using a convolutional neural network, calculation of volumetric bone mineral density (vBMD) with asynchronous calibration and TF extraction. Varianceglobal measures the spread of the gray-level distribution in an image while Entropy reflects the uniformity of gray-levels. Short-run emphasis (SRE), Long-run emphasis (LRE), Run-length non-uniformity (RLN) and Run percentage (RP) contain information on consecutive voxels of a particular grey-level, or grey-level range, in a particular direction. Long runs (LRE) represent coarse texture while short runs (SRE) represent fine texture. RLN reflects similarities in the length of runs while RP reflects distribution and homogeneity of runs with a specific direction. Results Six of the 24 extracted TFs had Δrel<5% (Varianceglobal, Entropy, SRE, LRE, RLN, RP), and were analyzed further in 4716 thoracolumbar vertebrae. Five TFs (Varianceglobal,SRE,LRE, RLN,RP) showed a significant difference between genders (p<0.001), potentially being caused by a finer and more directional vertebral trabecular microstructure in females compared to males. Varianceglobal and Entropy showed a significant increase from the thoracic to the lumbar spine (p<0.001), indicating a higher degree and earlier initiation of trabecular microstructure deterioration at lower spinal levels. The four higher-order TFs showed significant variations between spine regions without a clear directional gradient (p ≤ 0.001-0.012). No TF showed a clear age dependence. vBMD differed significantly between genders, age groups and spine regions (p ≤ 0.001–0.002). Conclusion Long-term reproducible CT-based TFs of the thoracolumbar spine were established and characterized in a predominantly older adult study population. The gender-, age- and vertebral-level-specific values may serve as foundation for osteoporosis diagnostics and facilitate future studies investigating vertebral microstructure.
Prädiktion der Wirbelkörperstabilität durch Texturanalyse von quantitativer MRT-Bildgebung / Deutsche Gesellschaft für Muskuloskeletale Radiologie e.V.
Subject headings[GND]: Computertomografie | Osteoporose
[MeSH]: Tomography, X-ray computed; Methods | Osteoporosis | Bone and bones; Anatomy and histology
[Free subject headings]: automated segmentation | texture analysis | multi-detector computed tomography | bone microstructure
[DDC subject group]: DDC 610 / Medicine & health
LicenseCC BY 4.0 International
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DOI & citation
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-46885