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AuthorDaria, Deidredc.contributor.author
Date of accession2017-10-27T10:58:12Zdc.date.accessioned
Available in OPARU since2017-10-27T10:58:12Zdc.date.available
Year of creation2015dc.date.created
Date of first publication2017-10-27dc.date.issued
AbstractThe G-protein coupled receptor 56 (GPR56) was identified as part of the molecular signature of leukemic stem cells isolated from patients with acute myeloid leukemia (AML), but the oncogenic potential of Gpr56 is unknown. This thesis demonstrates high expression of Gpr56 in the more primitive hematopoietic cells with decreased expression upon differentiation. Retroviral overexpression and transplant of Gpr56 in normal hematopoietic cells was not oncogenic and did not interfere with normal hematopoiesis. Increased Gpr56 expression in the context of Hoxa9 long-term cultures increased the aggressiveness of the disease by reducing the disease latency. Engraftment of human primary patient sample was reduced in the bone marrow upon the addition of an anti-GPR56 antibody. In summary, these data demonstrate that high expression of GPR56 is able to contribute to Hoxa9 induced AML development and provides a potential novel target for antibody-mediated anti-leukemic strategies.dc.description.abstract
Languageen_USdc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandarddc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v3dc.rights.uri
KeywordGPR56dc.subject
KeywordHomeobox protein HOXA9dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHReceptors, G-protein-coupleddc.subject.mesh
MeSHLeukemia, myeloid acutedc.subject.mesh
MeSHHomeodomain proteinsdc.subject.mesh
TitleDefining the role of G-coupled protein receptor Gpr56 in acute myeloid leukemiadc.title
Resource typeDissertationdc.type
Date of acceptance2016-11-11dcterms.dateAccepted
RefereeBuske, Christiandc.contributor.referee
RefereeGeiger, Hartmutdc.contributor.referee
DOIhttp://dx.doi.org/10.18725/OPARU-4533dc.identifier.doi
PPN1004696051dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-4572-1dc.identifier.urn
GNDG-Protein gekoppelte Rezeptorendc.subject.gnd
GNDAkute myeloische Leukämiedc.subject.gnd
GNDHomöodomänedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionUKU. Institut für Experimentelle Tumorforschunguulm.affiliationSpecific
InstitutionZentralinstitut für Biomedizinische Technik (ZIBMT)uulm.affiliationSpecific
Shelfmark print versionW: W-H 15.296uulm.shelfmark
Grantor of degreeMedizinische Fakultätuulm.thesisGrantor
DCMI TypeTextuulm.typeDCMI
TypeErstveröffentlichunguulm.veroeffentlichung
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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