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AuthorSattler, Arnedc.contributor.author
AuthorThumfart, Juliadc.contributor.author
AuthorTóth, Lauradc.contributor.author
AuthorSchrezenmeier, Evadc.contributor.author
AuthorProß, Vanessadc.contributor.author
AuthorStahl, Carolindc.contributor.author
AuthorSiegle, Janinedc.contributor.author
AuthorHe, Andc.contributor.author
AuthorThole, Linda Marie Lauradc.contributor.author
AuthorLudwig, Carolindc.contributor.author
AuthorStraub-Hohenbleicher, Henriettedc.contributor.author
AuthorFriedersdorff, Frankdc.contributor.author
AuthorJahrsdörfer, Bernddc.contributor.author
AuthorSchrezenmeier, Hubertdc.contributor.author
AuthorBufler, Philipdc.contributor.author
AuthorKotsch, Katjadc.contributor.author
Date of accession2022-09-26T07:29:41Zdc.date.accessioned
Available in OPARU since2022-09-26T07:29:41Zdc.date.available
Date of first publication2022-08-04dc.date.issued
AbstractProtection of adult kidney transplant recipients against SARS-CoV2 was shown to be strongly impaired owing to low reactogenicity of available vaccines. So far, data on vaccination outcomes in adolescents are scarce due to later vaccination approval for this age group. We therefore comprehensively analyzed vaccination-specific humoral-, T- and B-cell responses in kidney transplanted adolescents aged 12–18 years in comparison to healthy controls 6 weeks after standard two-dose BNT162b2 (“Comirnaty”; Pfizer/BioNTech) vaccination. Importantly, 90% (18/20) of transplanted adolescents showed IgG seroconversion with 75% (15/20) developing neutralizing titers. Still, both features were significantly diminished in magnitude compared to controls. Correspondingly, spike-specific B cells were quantitatively reduced and enriched for non-isotype-class-switched IgD+27+ memory cells in patients. Whereas spike specific CD4+ T cell frequencies were similar in both groups, cytokine production and memory differentiation were significantly impaired in transplant recipients. Although our data identify limitations in all arms of vaccine-specific immunity, the majority of our adolescent patients showed robust humoral responses despite antimetabolite-based treatment being associated with poor vaccination outcomes in adults.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordvaccinationdc.subject
KeywordSARS-CoV2dc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHKidney transplantationdc.subject.mesh
MeSHCOVID-19 vaccinesdc.subject.mesh
MeSHImmunitydc.subject.mesh
MeSHAdolescentdc.subject.mesh
TitleSARS-CoV2 mRNA vaccine-Specific B-, T- and humoral responses in adolescents after kidney transplantationdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2022-08-18T05:38:58Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-44793dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-44869-6dc.identifier.urn
GNDNierentransplantationdc.subject.gnd
GNDCOVID-19dc.subject.gnd
GNDImpfungdc.subject.gnd
GNDJugenddc.subject.gnd
GNDImmunität <Medizin>dc.subject.gnd
InstitutionUKU. Institut für Transfusionsmedizinuulm.affiliationSpecific
InstitutionInstitut für Klinische Transfusionsmedizin und Immungenetik Ulm gGmbH (IKT)uulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeCollectionuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3389/ti.2022.10677dc.relation1.doi
Source - Title of sourceTransplant Internationalsource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume35source.volume
Source - Year2022source.year
Source - Article number10677source.articleNumber
Source - eISSN1432-2277source.identifier.eissn
WoS000843204900001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.frontierspartnerships.org/articles/10.3389/ti.2022.10677/full#supplementary-materialdc.relation.isSupplementedBy


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