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AuthorChen, Kaidc.contributor.author
AuthorWang, Qidc.contributor.author
AuthorKornmann, Markodc.contributor.author
AuthorTian, Xiaodongdc.contributor.author
AuthorYang, Yinmodc.contributor.author
Date of accession2022-06-27T13:42:08Zdc.date.accessioned
Available in OPARU since2022-06-27T13:42:08Zdc.date.available
Date of first publication2021-02-26dc.date.issued
AbstractPancreatic ductal adenocarcinoma (PDAC) remains one of the most dismal gastrointestinal malignancies with an overall 5-year survival rate of 8%–9%. The intra-tumor heterogeneity and special tumor microenvironment in PDAC make it challenging to develop effective treatment strategies. Exosomes are extracellular vesicles that originate from the endosomes and have a diameter of 40–160 nm. A growing body of evidence has shown that exosomes play vital roles in tumor initiation and development. Recently, extensive application of exosomes as biomarkers and drug carriers has rendered them attractive in the field of PDAC. This review summarizes the latest progress in the methodologies for isolation, modification, and tracking of exosomes, exosome-mediated cell-to-cell communication, clinical applications of exosome as minimally invasive liquid biopsy and drugs carriers, as well as their involvement in the angiogenic regulation in PDAC. In spite of these advancements, some obstacles are still required to be overcome to use the exosome-based technologies for early diagnosis or improvement of prognosis of patients with PDAC.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordpancreatic cancerdc.subject
Keywordexosomedc.subject
Keywordcell-to-cell communicationdc.subject
Keywordtherapeutic vehicledc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHPancreatic neoplasmsdc.subject.mesh
MeSHBiomarkersdc.subject.mesh
MeSHExosomesdc.subject.mesh
TitleThe role of exosomes in pancreatic cancer from bench to clinical application: an updated reviewdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-03-12T08:37:28Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-43535dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-43611-1dc.identifier.urn
GNDBauchspeicheldrüsenkrebsdc.subject.gnd
GNDBiomarkerdc.subject.gnd
GNDExosom <Vesikel>dc.subject.gnd
InstitutionUKU. Klinik für Allgemein- und Viszeralchirurgieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeCollectionuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3389/fonc.2021.644358dc.relation1.doi
Source - Title of sourceFrontiers in Oncologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume11source.volume
Source - Year2021source.year
Source - Article number644358source.articleNumber
Source - eISSN2234-943Xsource.identifier.eissn
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000627753700001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie


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