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AuthorMytilineos, Daphnedc.contributor.author
AuthorTsamadou, Chrysanthidc.contributor.author
AuthorNeuchel, Christinedc.contributor.author
AuthorPlatzbecker, Uwedc.contributor.author
AuthorBunjes, Donalddc.contributor.author
AuthorSchub, Nataliedc.contributor.author
AuthorWagner-Drouet, Evadc.contributor.author
AuthorWulf, Geralddc.contributor.author
AuthorKröger, Nicolausdc.contributor.author
AuthorMurawski, Nielsdc.contributor.author
AuthorEinsele, Hermanndc.contributor.author
AuthorSchaefer-Eckart, Kerstindc.contributor.author
AuthorFreitag, Sebastiandc.contributor.author
AuthorCasper, Jochendc.contributor.author
AuthorKaufmann, Martindc.contributor.author
AuthorDürholt, Mareikedc.contributor.author
AuthorHertenstein, Bernddc.contributor.author
AuthorKlein, Stefandc.contributor.author
AuthorRinghoffer, Markdc.contributor.author
AuthorMueller, Carlheinz R.dc.contributor.author
AuthorFrank, Sandradc.contributor.author
AuthorSchrezenmeier, Hubertdc.contributor.author
AuthorFuerst, Danieldc.contributor.author
AuthorMytilineos, Joannisdc.contributor.author
Date of accession2022-06-27T13:27:46Zdc.date.accessioned
Available in OPARU since2022-06-27T13:27:46Zdc.date.available
Date of first publication2021-01-25dc.date.issued
AbstractT-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts. We retrospectively genotyped HLA-DPB1 in 3523 patients transplanted in Germany between 2000 and 2014 and in their unrelated donors using an Illumina amplicon-NGS based assay. Aim of the study was to evaluate DP-compatibility beyond the established TCE3 algorithm by assessing the combined effect of several DP-mismatch parameters on post-transplant outcome. We implemented an extended DP-mismatch assessment model where TCE3, DP allotype expression with respect to rs9277534, mismatch vector and number of mismatches were conjointly taken into consideration. In this model, non-permissive HLA-DPB1 mismatches showed significantly increased aGvHD risk if they were accompanied by two HLA-DPB1 mismatches in GvH direction (HR: 1.46) or one mismatched highly expressed patient allotype (HR: 1.53). As previously reported, non-permissive HLA-DPB1 mismatches associated with a significantly higher risk of aGvHD and non-relapse mortality (HR 1.36 and 1.21, respectively), which in turn translated into worse GvHD and relapse free survival (HR 1.13). Effects on GvL and GvHD appeared strongest in GvH-directed non-permissive mismatches. Our study results support the consideration of additional HLA-DPB1 mismatch parameters along with the established TCE3 matching algorithm for refinement of future donor selection. In particular, our findings suggest that DP non-permissiveness associated with two HLA-DPB1 mismatches or at least on highly expressed mismatched patient allotype should be avoided.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordgraft-versus-host-diseasedc.subject
KeywordHLA-DPB1dc.subject
KeywordHLA-DPB1 expressiondc.subject
KeywordHLA-DPB1-permissivenessdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHStem cell transplantationdc.subject.mesh
MeSHGraft vs host diseasedc.subject.mesh
TitleThe human leukocyte antigen-DPB1 degree of compatibility is determined by its expression level and mismatch permissiveness: a german multicenter analysisdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-02-08T06:07:46Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-43533dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-43609-4dc.identifier.urn
GNDPeriphere Stammzellentransplantationdc.subject.gnd
GNDTransplantat-Wirt-Reaktiondc.subject.gnd
InstitutionInstitut für Klinische Transfusionsmedizin und Immungenetik Ulm gGmbH (IKT)uulm.affiliationSpecific
InstitutionUKU. Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgieuulm.affiliationSpecific
InstitutionUKU. Institut für Transfusionsmedizinuulm.affiliationSpecific
InstitutionUKU. Klinik für Innere Medizin IIIuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeCollectionuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3389/fimmu.2020.614976dc.relation1.doi
Source - Title of sourceFrontiers in Immunologysource.title
Source - Place of publicationFrontiers Mediasource.publisher
Source - Volume11source.volume
Source - Year2021source.year
Source - Article number3389source.articleNumber
Source - eISSN1664-3224source.identifier.eissn
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000615808700001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttps://www.frontiersin.org/articles/10.3389/fimmu.2020.614976/full#supplementary-materialdc.relation.isSupplementedBy


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