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AuthorSchilling, Eva-Mariadc.contributor.author
AuthorScherer, Myriamdc.contributor.author
AuthorStamminger, Thomasdc.contributor.author
Date of accession2022-06-27T13:12:08Zdc.date.accessioned
Available in OPARU since2022-06-27T13:12:08Zdc.date.available
Date of first publication2021-01-26dc.date.issued
AbstractCellular restriction factors (RFs) act as important constitutive innate immune barriers against viruses. In 2006, the promyelocytic leukemia protein was described as the first RF against human cytomegalovirus (HCMV) infection which is antagonized by the viral immediate early protein IE1. Since then, at least 15 additional RFs against HCMV have been identified, including the chromatin regulatory protein SPOC1, the cytidine deaminase APOBEC3A and the dNTP triphosphohydrolase SAMHD1. These RFs affect distinct steps of the viral replication cycle such as viral entry, gene expression, the synthesis of progeny DNA or egress. This review summarizes our current knowledge on intrinsic immune mechanisms restricting HCMV replication as well as on the viral strategies to counteract the inhibitory effects of RFs. Detailed knowledge on the interplay between host RFs and antagonizing viral factors will be fundamental to develop new approaches to combat HCMV infection.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseCC BY 4.0 Internationaldc.rights
Link to license texthttps://creativecommons.org/licenses/by/4.0/dc.rights.uri
Keywordrestriction factordc.subject
Keywordintrinsic immunitydc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHCytomegalovirus; Immunologydc.subject.mesh
MeSHAntiviral restriction factorsdc.subject.mesh
TitleIntrinsic immune mechanisms restricting human cytomegalovirus replicationdc.title
Resource typeWissenschaftlicher Artikeldc.type
SWORD Date2021-02-04T09:56:36Zdc.date.updated
VersionpublishedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-43531dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-43607-1dc.identifier.urn
GNDCytomegalie-Virusdc.subject.gnd
InstitutionUKU. Institut für Virologieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.3390/v13020179dc.relation1.doi
Source - Title of sourceVirusessource.title
Source - Place of publicationMDPIsource.publisher
Source - Volume13source.volume
Source - Issue2source.issue
Source - Year2021source.year
Source - Article number179source.articleNumber
Source - eISSN1999-4915source.identifier.eissn
Open AccessDOAJ Gold, Green Publisheduulm.OA
WoS000623307400001uulm.identifier.wos
Bibliographyuulmuulm.bibliographie
DFG project uulmnterferenzmechanismen der viralen Effektorproteine pp71 und IE1 mit der ND10-vermittelten intrinsischen Immunität gegen Cytomegalovirus-Infektionen Teilprojekt B03 / DFG / 52732026 [STA357/7-1]uulm.projectDFG


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